*To all members of the beg-evodevo maillist: *
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Very interesting paper revealing:
-that the number of conserved non-genic sequences shared between
mammalian and fish genomes is at least an order of magnitude higher than
previously proposed and is spread across thousands of genes (i.e. not
restricted to trans-dev genes). The trick is to search not using global
alignments, but allowing for reshuffling of conserved elements (only 1/3
is positionally conserved between fish/mammalia).
-apparently the first 1kb upstream of TSS seems more rigid, explaining
why for e.g. HOX genes (e.g. trans-dev) global alignments approaches
work as good as local alignment approaches.
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Klaas Vandepoele, PhD
Tel. 32 (0)9 3313822
DEPARTMENT OF PLANT SYSTEMS BIOLOGY
VIB/GHENT UNIVERSITY, Technologiepark 927, B-9052 Gent, Belgium
E-mail: Klaas.Vandepoele(a)psb.ugent.be
Website: http://bioinformatics.psb.ugent.be/
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