title: The complex relationship of gene duplication and essentiality by: Takashi Makino, Karsten Hokamp and Aoife McLysaght TRENDS IN GENETICS Volume: 25 Issue: 4 Pages: 152-155 Published: APR 2009 abstract: In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons.Weshow that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes. -- ================================================================== Tine Blomme Tel:+32 (0)9 331 38 22 fax:+32 (0)9 3313809 VIB Department of Plant Systems Biology, Ghent University Technologiepark 927, 9052 Gent, BELGIUM tiblo@psb.vib-ugent.be http://www.psb.vib-ugent.be ==================================================================