This method proposes a nice (relative-treshold based) method to select relevant homologs suitable that should work well for both fast/slowly evolving genes. For details, see Materials & Methods section & Figure 6. http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0000019 -- ================================================================== Klaas Vandepoele, PhD Tel. 32 (0)9 33 13822 VIB Department of Plant Systems Biology, UGent Technologiepark 927, B-9052 Gent, Belgium E-mail: Klaas.Vandepoele@psb.ugent.be Website: http://bioinformatics.psb.ugent.be/ ==================================================================