January 2008 - beg-sysbiol@psb.ugent.be

[Beg-sysbiol] are you guys doing something separate are are you joining for the pizzahut ... let me know Yves
by Yves Van de Peer 01 Feb '08

01 Feb '08

-------- Original Message -------- Subject: de pizzahut de pizzahut... Date: Thu, 31 Jan 2008 17:19:01 +0100 From: Steven Robbens <steven.robbens(a)psb.ugent.be> To: Bioinformatics & Evolutionary Genomics <beg(a)psb.ugent.be>, Jan Wuyts <jan.wuyts(a)gmail.com> who's joining tomorrow for lunch in the pizzahut...?? An old (or let's say former) colleague is joining as well.... As the famous buffet starts at 12 o'clock, I suggest to leave here around 11h45. Greetz, BBQ-strob -- ================================================================== Steven Robbens VIB Department of Plant Systems Biology, UGent Bioinformatics and Evolutionary Genomics Technologiepark 927 B-9052 Gent Belgium Tel: 32 (0)9 3313692 Website: http://bioinformatics.psb.ugent.be ================================================================== -- Yves Van de Peer, PhD. Professor in Bioinformatics and Genome Biology Group Leader Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Ghent University Technologiepark 927 B-9052 Ghent Belgium Phone: +32 (0)9 331 3807 Cell Phone: +32 (0)476 560 091 Fax: +32 (0)9 331 3809 email: yves.vandepeer(a)psb.ugent.be http://bioinformatics.psb.ugent.be/

3 2

[Beg-sysbiol] weekly meetings ?
by Steven Maere 31 Jan '08

31 Jan '08

Dear all, I sent a mail a while ago in an attempt to revive our weekly friday afternoon meetings to keep track of what everybody's doing. Most, if not all of us agreed that that would be useful, but somehow we didn't put it into practice yet. How about this friday 16.00 ? S -- ================================================================== Steven Maere, PhD Dept. of Plant Systems Biology Bioinformatics & Evolutionary Genomics research group VIB / Ghent University Technologiepark 927 B-9052 Gent BELGIUM tel: +32 9 331 3810 fax: +32 9 331 3809 email: stmae(a)psb.UGent.be http://www.psb.UGent.be http://bioinformatics.psb.ugent.be/ ==================================================================

9 14

[Beg-sysbiol] sysbiol meeting
by Eric Bonnet 30 Jan '08

30 Jan '08

so to keep everybody posted, we just had a sysbiol meeting with PIs in the lab. The goal was to present some preliminary results that we produced by applying the enigma and lemone algorithms on the Arabidopsis compendium dataset (~20,000 genes x ~500 experiments). Steven explained briefly how we build the dataset and how enigma works then Tom explained a bit the mysteries underlying lemone. Some modules were shown and discussed. The practical conclusion was basically that we will organize groups to study more in details interesting enigma and lemone modules. There will be a group on cell cycle (obviously) with Dirk, Lieven and others, a group on stress related processes with other people and so on. The idea is to improve and refine the modules by discussing their relevance with the biological experts. You can find the presentation, an excel sheet compiling the enigma and lemone modules and the figures under p:/users/erbon/ath_cc/ To be continued... Eric

1 0

[Beg-sysbiol] Regulatory network reconstruction using an integra...[BMC Syst Biol. 2008] - PubMed Result
by Yves Van de Peer 27 Jan '08

27 Jan '08

http://www.ncbi.nlm.nih.gov/pubmed/18218091?dopt=Abstract -- Yves Van de Peer, PhD. Professor in Bioinformatics and Genome Biology Group Leader Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Ghent University Technologiepark 927 B-9052 Ghent Belgium Phone: +32 (0)9 331 3807 Cell Phone: +32 (0)476 560 091 Fax: +32 (0)9 331 3809 email: yves.vandepeer(a)psb.ugent.be http://bioinformatics.psb.ugent.be/

1 0

[Beg-sysbiol] [Fwd: Fw: Important Notice on DREAM2 data]
by Yves Van de Peer 25 Jan '08

25 Jan '08

-------- Original Message -------- Subject: Fw: Important Notice on DREAM2 data Date: Thu, 24 Jan 2008 23:38:55 -0500 From: Gustavo Stolovitzky <gustavo(a)us.ibm.com> To: DREAM2 Authors of Accepted Posters <DREAM2_Authors_of_Accepted_Posters%IBMUS(a)us.ibm.com>, DREAM2 Authors of Accepted Submissions <DREAM2_Authors_of_Accepted_Submissions%IBMUS(a)us.ibm.com>, DREAM2 Registrants <DREAM2_Registrants%IBMUS(a)us.ibm.com> Neil and all, Here is a conundrum: 1) We all agree that the DREAM exercise would be most useful with full disclosure of the gold standards. 2) However, in order to obtain data for the DREAM challenges we need to ensure that the data owners feel comfortable enough sharing that information before publication. In the case of the BCL6 target challenge, the fact that Neil Clarke could figure out which the gold standards were from the PR and ROC curves allowed him to get to richer conclusions than he could have obtained without that information. (those are the conclusions that make DREAM useful). I believe that Neil should be able to use that information provided that he doesn't disclose the true postive and negatives before publication by Andrea and collaborators. Andrea, you are the owner of that data: is that fine with you? I agree with Neil that providing the target identity to facilitate analyses with the commitment of the participants to not disclose the actual targets, would not affect in any way the data owner's ability to publish. But the data owners will have the last word on this. It would be nice if we continued this discussion in the DREAM discussion forum, at: http://wiki.c2b2.columbia.edu/dream/discuss/ Neil: can you add your comments to the website? Gustavo Gustavo A. Stolovitzky, Ph.D. Adj. Assoc Prof of Biomed Informatics, Columbia Univ Mngr, Func Genomics & Sys Biology, IBM Research P.O.Box 218 Office : (914) 945-1292 Yorktown Heights, NY 10598 Fax : (914) 945-4217 http://www.research.ibm.com/people/g/gustavo http://domino.research.ibm.com/comm/research_projects.nsf/pages/fungen.inde… *Neil Clarke <clarken(a)gis.a-star.edu.sg>* 01/24/2008 09:11 PM To Gustavo Stolovitzky/Watson/IBM@IBMUS, DREAM2 Authors of Accepted Posters <DREAM2_Authors_of_Accepted_Posters%IBMUS(a)us.ibm.com>, DREAM2 Authors of Accepted Submissions <DREAM2_Authors_of_Accepted_Submissions%IBMUS(a)us.ibm.com>, DREAM2 Registrants <DREAM2_Registrants%IBMUS(a)us.ibm.com> cc <califano(a)c2b2.columbia.edu>, <haiyuan_yu(a)DFCI.HARVARD.EDU>, <piacosma(a)tigem.it>, <pedro.mendes(a)manchester.ac.uk>, <boris(a)borisland.com>, <boris(a)gnsbiotech.com>, <tgardner(a)bu.edu>, <jpaul(a)nyas.org> Subject Re: Important Notice on DREAM2 data Dear all, particularly those of you who defined the gold standard BCL6 targets for Challenge #1: In order to figure out what worked - and, more importantly, what failed - we *have* to be able to use the list of "gold standards". Fortunately, I *do* know which of the 200 genes we were given were considered true positives. I was able to extract that information from the precision-recall and ROC curves provided to us by the organizers, based on our prediction. This knowledge of the "gold standard" set is absolutely essential to analyzing what worked and what didn't. Those of you who were in NY may remember that I used that knowledge to show that we would have been much better off if we had only used our expression data analysis. We hurt ourselves considerably trying to include gene ontologies, predicted binding sites, ARACNe, publically available ChIP data, etc. Without knowing what the gold standard set was, I would not have been able to figure this out. I would gotten up and said that we did all these different things, and you (and I) would probably have come to the conclusion that we did something smart by incorporating these different terms. In fact, that's the wrong conclusion, but the only way we know that its wrong that is because I was able to figure out what was considered the gold standard set. The talk would have been almost meaningless without this - and the same goes for the paper that we are writing. I have no intention of identifying the gold standard genes in my paper. There wouldn't be any point, anyway - it doesn't matter to the analysis what the gene names are. However, I *do* need to do analyses that rely on knowing which of the genes are in the gold standard set. I honestly don't see how these analyses could possibly infringe upon the intellectual property of those providing the Challenge set, or affect in any way their ability to publish or patent. However, if anyone disagrees with this, I would welcome further discussion before we get much further in the publication process. Thanks! Neil > Dear DREAM participants, > > You may remember that when you registered for the datasets in DREAM2 there > was the notice inthe DREAM website stating > > > > Important Notice > > These datasets cannot be used for external publication without explicit > permission from the data owners. > > The reason for this notice was that the people facilitating the data did > so, in some cases, before their data was published. > > In particular: > > Challenge #1: BCL6 targets challenge: > The gold standard will be posted when the owners get their papers > published. After which you will be able to use this data for your > publication purposes. > For questions about this challenge, please contact < > califano(at)c2b2.columbia.edu> > > Challenge #2: Protein-Protein interaction challenge. > The gold standards is posted in our website. Please contact Haiyuan Yu > <haiyuan_yu(at)dfci.harvard.edu> for permision to use the data. > > Challenge #3: The five-gene-network challenge. > The gold standard is posted in our website. However, the original data has > not been published by the data producers yet. Please contact Pia Cosma > <piacosma(at)tigem.it> for authorization to use the data in any form. If > you are using it for our Proceedings in the Annals of the NY Academy of > Sciences, > please do not mention that the data were obtained from a synthetic > network, do not mention that it is coming from yeast, do not plot the qPCR > data. Do not > show the actual network topology. When referring to this data, please > refer to the "DREAM five-gene-network challenge, Cantone et al, > unpublished data" > as a reference, until this work is published by Pia and colaborators. > > Challenge #4: The Insilico network challenge. > The gold standard is posted in our website. This data can be used without > problem. It was generated by Pedro Mendes. Please refer to > Pedro Mendes and the DREAM project if you use this data. For questions on > this data, please contact Pedro at: <pedro.mendes(at)manchester.ac.uk> > > > Challenge #5: The Genome-scale network challenge. > The gold standard is posted in our website. This data can be used without > problem. It was generated in Tim Gardner's lab, and curated by Boris > Hayete. > Please refer to Tim Gardner and Boris Hayete and the DREAM project if you > use this data. For questions on this data, please contact Boris at > <boris(at)borisland.com> > > Thanks for your understanding and help on this. > > Gustavo > > > > > Gustavo A. Stolovitzky, Ph.D. > Adj. Assoc Prof of Biomed Informatics, Columbia Univ > Mngr, Func Genomics & Sys Biology, IBM Research > P.O.Box 218 Office : (914) 945-1292 > Yorktown Heights, NY 10598 Fax : (914) 945-4217 > http://www.research.ibm.com/people/g/gustavo > http://domino.research.ibm.com/comm/research_projects.nsf/pages/fungen.inde… > tml -- Neil Clarke Deputy Director Genome Institute of Singapore phone: (65) 6478 8005 60 Biopolis St #02-01 Genome Singapore 138672 Required notice: ------------------------------------------------------------------------- This email is confidential and may be privileged. If you are not the intended receipient, please delete it and notify us immediately. Please do not copy or use it for any purpose, or disclose its contents to any other person. Thank you. -------------------------------------------------------------------------- -- Yves Van de Peer, PhD. Professor in Bioinformatics and Genome Biology Group Leader Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Ghent University Technologiepark 927 B-9052 Ghent Belgium Phone: +32 (0)9 331 3807 Cell Phone: +32 (0)476 560 091 Fax: +32 (0)9 331 3809 email: yves.vandepeer(a)psb.ugent.be http://bioinformatics.psb.ugent.be/

1 0

[Beg-sysbiol] [Fwd: Important Notice on DREAM2 data]
by Yves Van de Peer 25 Jan '08

25 Jan '08

-------- Original Message -------- Subject: Important Notice on DREAM2 data Date: Thu, 24 Jan 2008 18:24:29 -0500 From: Gustavo Stolovitzky <gustavo(a)us.ibm.com> To: DREAM2 Authors of Accepted Posters <DREAM2_Authors_of_Accepted_Posters%IBMUS(a)us.ibm.com>, DREAM2 Authors of Accepted Submissions <DREAM2_Authors_of_Accepted_Submissions%IBMUS(a)us.ibm.com>, DREAM2 Registrants <DREAM2_Registrants%IBMUS(a)us.ibm.com> CC: Gustavo Stolovitzky <gustavo(a)us.ibm.com>, califano(a)c2b2.columbia.edu, haiyuan_yu(a)DFCI.HARVARD.EDU, piacosma(a)tigem.it, pedro.mendes(a)manchester.ac.uk, boris(a)borisland.com, boris(a)gnsbiotech.com, tgardner(a)bu.edu Dear DREAM participants, You may remember that when you registered for the datasets in DREAM2 there was the notice inthe DREAM website stating Important Notice These datasets cannot be used for external publication without explicit permission from the data owners. The reason for this notice was that the people facilitating the data did so, in some cases, before their data was published. In particular: *Challenge #1: BCL6 targets challenge:* The gold standard will be posted when the owners get their papers published. After which you will be able to use this data for your publication purposes. For questions about this challenge, please contact <califano(at)c2b2.columbia.edu> *Challenge #2: Protein-Protein interaction challenge.* The gold standards is posted in our website. Please contact Haiyuan Yu <haiyuan_yu(at)dfci.harvard.edu> for permision to use the data. *Challenge #3: The five-gene-network challenge. * The gold standard is posted in our website. However, the original data has not been published by the data producers yet. Please contact Pia Cosma <piacosma(at)tigem.it> for authorization to use the data in any form. If you are using it for our Proceedings in the Annals of the NY Academy of Sciences, please do not mention that the data were obtained from a synthetic network, do not mention that it is coming from yeast, do not plot the qPCR data. Do not show the actual network topology. When referring to this data, please refer to the "DREAM five-gene-network challenge, Cantone et al, unpublished data" as a reference, until this work is published by Pia and colaborators. *Challenge #4: The Insilico network challenge. * The gold standard is posted in our website. This data can be used without problem. It was generated by Pedro Mendes. Please refer to Pedro Mendes and the DREAM project if you use this data. For questions on this data, please contact Pedro at: <pedro.mendes(at)manchester.ac.uk> *Challenge #5: The Genome-scale network challenge.* The gold standard is posted in our website. This data can be used without problem. It was generated in Tim Gardner's lab, and curated by Boris Hayete. Please refer to Tim Gardner and Boris Hayete and the DREAM project if you use this data. For questions on this data, please contact Boris at <boris(at)borisland.com> Thanks for your understanding and help on this. Gustavo Gustavo A. Stolovitzky, Ph.D. Adj. Assoc Prof of Biomed Informatics, Columbia Univ Mngr, Func Genomics & Sys Biology, IBM Research P.O.Box 218 Office : (914) 945-1292 Yorktown Heights, NY 10598 Fax : (914) 945-4217 http://www.research.ibm.com/people/g/gustavo http://domino.research.ibm.com/comm/research_projects.nsf/pages/fungen.inde… -- Yves Van de Peer, PhD. Professor in Bioinformatics and Genome Biology Group Leader Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Ghent University Technologiepark 927 B-9052 Ghent Belgium Phone: +32 (0)9 331 3807 Cell Phone: +32 (0)476 560 091 Fax: +32 (0)9 331 3809 email: yves.vandepeer(a)psb.ugent.be http://bioinformatics.psb.ugent.be/

1 0

[Beg-sysbiol] [Fwd: India Is Connexios' Competitive Advantage]
by Eric Bonnet 23 Jan '08

23 Jan '08

Hey Anagha, time to start your start-up company !!

1 0

[Beg-sysbiol] Prioritization of gene regulatory interactions from large-scale modules in yeast
by Eric Bonnet 23 Jan '08

23 Jan '08

http://www.biomedcentral.com/1471-2105/9/32/abstract

1 0

[Beg-sysbiol] Anyone interested to replace me and to give a general talk on Systems and Integrative Biology?
by Yves Van de Peer 23 Jan '08

23 Jan '08

-------- Original Message -------- Subject: RE: VIB Seminar: selected keynote speakers for parallel sessions Date: Wed, 23 Jan 2008 09:23:06 +0100 From: Ann Van Gysel <Ann.VanGysel(a)vib.be> To: Yves Van de Peer <yves.vandepeer(a)psb.ugent.be> CC: Inge Geysen <Inge.Geysen(a)vib.be> References: <768DE2AF5788D94B9F33A65DC49185BD03FECC2D@vibserv7> <47964F22.7010409(a)psb.ugent.be> Dag Yves Dat is spijtig (voor ons dan), Maar Trentino zal beter zijn voor jou. Is er iemand van jouw team/naaste collega's die hiervoor in aanmerking zou komen? MVG Ann -----Original Message----- From: Yves Van de Peer [mailto:yves.vandepeer@psb.ugent.be] Sent: dinsdag 22 januari 2008 21:17 To: Ann Van Gysel Subject: Re: VIB Seminar: selected keynote speakers for parallel sessions Beste Ann, Bedankt voor de mail en het vertrouwen, maar spijtig genoeg ben ik niet in het land dan. Ik zit namelijk in Italie (Trentino) dan om over het appelgenoom te spreken. Sorry daarvoor. Met vriendelijke groeten, Yves > > Dear colleague, > > I am happy to inform you that you have been selected as a *VIB-keynote > speaker* to give an introduction in the parallel science sessions at > the VIB seminar, March 6 2008: > > session 1 > > /Rudi Beyaert: Cancer biology and Cell Death/ > > Patrick De Baetselier: /Immunology and Molecular Medicine/ > > session 2 > > Diether Lambrechts: /Cell and Developmental Biology/ > > Bassem Hassan: /Neuroscience// > /session 3// > > Johan Thevelein: /Signal Transduction and Gene Regulation / > > Albena Jordanova: /Genetics// > /session 4// > > Kris Gevaert: /Protein Structure Function and Analysis / > > Yves Van de Peer: /Systems and Integrative Biology/ > > The Organizing Committee introduced a new feature to this years' > seminar; to make the parallel science sessions more accessible for all > researchers, the parallel sessions - each covering two science topics > - will start with an introduction on each of these two topics. The aim > of these keynote talks (30' each) is to give a very general > introduction to that specific research area, covering the current > knowledge and research results. You can compare it with a 30' review > on that specific topic. Please note that you are NOT to elaborate for > 30' on your own research results; but of course if you have relevant > topics, you can refer to them, but surely not in detail. Please refer > to the posters of your group members for your research details. > > I am aware that this will mean a bit more work, but I am sure you > understand that such an introduction can be of great value to the > younger scientists and researchers from other fields. I know you are > expert in this area and I am convinced your presentation will be of > great value to all researchers. You have been selected by the > Organizing Committee based on your research experience and speaking > skills. > > For your information, the two keynote talks are followed by 4 short > talks (15') which will be selected by the OC from the submitted > abstracts. The selected abstracts will be forwarded to you on January > 29; perhaps they can be of use to you. > > I trust you are willing to accept this invitation; thank you for > confirming this before *January 28*. Please note that your abstract is > due on February 8. I am a aware that some of you didn't put themselves > forward as a candidate, but we hope you will accept our invitation > anyway. In addition, some of you are not yet registered; please let us > know if you will be needing accommodation. > > Looking forward to your reply. > > With kind regards > > Ann > > ----------------------------------------- > Ann Van Gysel, PhD > > Communicatiemanager > > *VIB > *Rijvisschestraat 120 > 9052 GENT > BELGIE > Tel. +32 9 244 66 11 > Fax +32 9 244 66 10 > E-mail: ann.vangysel(a)vib.be <mailto:ann.vangysel@vib.be> > > Website: www.vib.be <http://www.vib.be/> > ----------------------------------------- > -- Yves Van de Peer, PhD. Professor in Bioinformatics and Genome Biology Group Leader Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Ghent University Technologiepark 927 B-9052 Ghent Belgium Phone: +32 (0)9 331 3807 Cell Phone: +32 (0)476 560 091 Fax: +32 (0)9 331 3809 email: yves.vandepeer(a)psb.ugent.be http://bioinformatics.psb.ugent.be/ -- Yves Van de Peer, PhD. Professor in Bioinformatics and Genome Biology Group Leader Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Ghent University Technologiepark 927 B-9052 Ghent Belgium Phone: +32 (0)9 331 3807 Cell Phone: +32 (0)476 560 091 Fax: +32 (0)9 331 3809 email: yves.vandepeer(a)psb.ugent.be http://bioinformatics.psb.ugent.be/

1 0

[Beg-sysbiol] at home
by vamei＠psb.ugent.be 18 Jan '08

18 Jan '08

Hi everybody, I still have some backache and therefore will not come to work today. Greetings, Vanessa

1 0