Yves Van de Peer wrote:
-------- Original Message -------- Subject: Subject: Invitation to review for Molecular Systems Biology - MSB-10-2067 Date: Tue, 20 Apr 2010 12:26:35 -0400 From: msb@embo.org To: yvpee@psb.ugent.be
***PLEASE DO NOT REPLY TO THIS EMAIL*** *** USE THE LINKS BELOW INSTEAD ***
Dear Prof Van de Peer,
Would you (or a senior member of your lab) be prepared to review the manuscript below for us within 21 days of receipt? WOULD YOU NEED MORE TIME?
Manuscript Reference: MSB-10-2067 Authors: Todd Treangen and Eduardo Rocha Title: Prevalence of xenology over paralogy shapes the evolution of prokaryotic systems Type of Article: Article
Abstract: Gene duplication is regarded as the main source of adaptive functional novelty in eukaryotes. Adaptive gene duplication has also been proposed to outweigh the contribution of horizontal gene transfer in gene family expansion in prokaryotes. Using many closely related genomes and after explicitly controlling for transposable and phage elements in a population genomics framework, we show that the vast majority of gene family expansions in prokaryotes are due to transfer, especially among larger genomes. Transferred genes persist longer in genomes, suggesting a higher/longer adaptive role. Duplicated genes are more expressed and evolve slower at synonymous and non-synonymous positions suggesting selection for gene dosage and frequent gene conversion. Importantly, pairs of duplicated genes share most protein-protein interactions and genetic regulators, but transferred genes share very few. Thus, transfer outweighs duplication in the expansion of gene families and due to the high divergence of xenologs produces very different adaptive paths for prokaryotic biological systems. Since prokaryotes invented the majority of life's biochemical diversity, models of network evolution should explicitly account for the role of horizontal gene transfer.
Please click on the appropriate link: to ACCEPT, <http://mts-msb.nature.com/cgi-bin/main.plex?el=A6BL2BGK3A4Dct4D2A98G1FQKjv38eIDx9btpsqgZ>
to DECLINE, <http://mts-msb.nature.com/cgi-bin/main.plex?el=A4BL1BGK1A5Dct3E1A98G1FQKjv38eIDx9btpsqgZ>
If you are unable to review this manuscript at this time, I would be grateful if you could forward suggestions of other potential reviewers. You can do this by using the "Send Manuscript Correspondence" option when declining or by email to msb@embo.org.
Should you have any problems entering the site, please e-mail msb@nature.com.
Thank you for your consideration and support of Molecular Systems Biology.
Yours sincerely,
Andrew L. Hufton, PhD Section Editor Molecular Systems Biology
Please note that your contact details are being held on our editorial database which is used only for this journal's management of the peer review process. If you would prefer us not to contact you in the future please let us know by emailing msb@nature.com.
MSB - This email has been sent through the NPG Manuscript Tracking System NY-610A-NPG&MTS
ik wil wel! -- ===================================================================== Vanessa Vermeirssen, PhD Tel:+32 (0)9 331 38 10 Fax:+32 (0)9 3313809 Bioinformatics and Systems Biology VIB Department of Plant Systems Biology, Ghent University Technologiepark 927, 9052 Gent, BELGIUM vamei@psb.vib-ugent.be http://bioinformatics.psb.ugent.be/ ======================================================================