[Beg-sysbiol] A Chemical Kinetic Model of Transcriptional Elongation

-------- Original Message -------- Subject: q-bio daily Subj-class mailing 8 1 Date: Tue, 14 Mar 2006 05:04:33 -0500 From: no-reply@arXiv.org (send mail ONLY to q-bio) Reply-To: q-bio@arXiv.org To: rabble@arXiv.org (q-bio daily title/abstract distribution) ------------------------------------------------------------------------------ ------------------------------------------------------------------------------ send mail only to q-bio@arXiv.org, do not reply to no-reply@... send any complaints regarding submissions directly to submitter. use a single `get' to request multiple papers, `list macros' for available macro packages, and `help' for a list of available commands and other info. ------------------------------------------------------------------------------ point your www client at http://arXiv.org/ To unsubscribe, e-mail To: q-bio@arXiv.org, Subject: cancel ------------------------------------------------------------------------------ Submissions to: Subcellular Processes received from Fri 10 Mar 06 21:00:02 GMT to Mon 13 Mar 06 21:00:02 GMT ------------------------------------------------------------------------------ %-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%- ------------------------------------------------------------------------------ \\ Paper: q-bio.BM/0603012 Date: Sun, 12 Mar 2006 02:50:18 GMT (77kb) Title: A Chemical Kinetic Model of Transcriptional Elongation Authors: Yujiro Richard Yamada, Charles S. Peskin Comments: 12 pages, 4 figures Subj-class: Biomolecules; Subcellular Processes \\ A chemical kinetic model of the elongation dynamics of RNA polymerase along a DNA sequence is introduced. Unlike previous models that attempt to explain the motion of RNA polymerase using internal strain and stresses, we propose a chemical kinetic model which governs the discrete movement of the RNA polymerase along a DNA tether, with no consideration given to elastic effects. The model's novel concept is a ``look-ahead'' feature, in which nucleotides bind reversibly to the DNA prior to being incorporated covalently into the nascent RNA chain. Results are presented for specific DNA sequences that have been used in single-molecule experiments of the random walk of RNA polymerase along DNA. \\ ( http://arXiv.org/abs/q-bio/0603012 , 77kb) %%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%% %%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%--- -- Roeland Merks Department of Plant Systems Biology VIB / Ghent University Technologiepark 927 B-9052 Ghent, Belgium http://www.psb.ugent.be Tel. +32-(0)9-33 13825 email: post@roelandmerks.nl http://www.roelandmerks.nl weblog: http://biolog.volkskrantblog.nl
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Roeland Merks