-------- Original Message -------- Subject: DREAM3 Biological Prediction Challenges Date: Wed, 18 Jun 2008 00:34:57 -0400 From: Gustavo Stolovitzky <gustavo@us.ibm.com> To: Gustavo Stolovitzky <gustavo@us.ibm.com> PLEASE LET ME KNOW IF YOU PREFER NOT TO RECEIVE ANNOUNCEMENTS FROM THE DREAM PROJECT SINCERE APOLOGIES IF YOU RECEIVE THIS ANNOUNCEMENT MORE THAN ONCE *Call for Network Inference and Biological Predictions* *DREAM 3 * *The 3rd DIALOGUE ON REVERSE ENGINEERING * *ASSESSMENT AND METHODS* Dear Colleague, We would like to cordially invite you to submit network inferences and answers to our new biological prediction challenges. To access the data sets, and descriptions of the challenges, please go to http://wiki.c2b2.columbia.edu/dream/index.php/The_DREAM3_Challenges. The best performers in these challenges will be invited to present in the joint RECOMB Systems Biology/Regulatory Genomics/DREAM3 conference. See _http://compbio.mit.edu/recombsat/_ for details on this conference. To learn more about the DREAM3 conference, please go to http://wiki.c2b2.columbia.edu/dream/index.php/The_3rd_DREAM_Conference To learn more about the DREAM project, please go to http://wiki.c2b2.columbia.edu/dream/index.php/The_DREAM_Project *Network Inference and Predictions Submission Timeline* Mid June, 2008 Call for participation in the challenges. Challenges posted. Sep 15, 2008 Predictions Submission deadline. Oct 15, 2008 Notifications to predictors of their scores and ranks. Oct 29-Nov 2, 2008 RECOMB Systems Biology/Regulatory Genomics/DREAM3 conference. (The DREAM3 conference track is on October 31.) Prediction Submissions must be received in electronic form by 11:59pm (EST) of Sep 15, 2008. Sincerely, DREAM3 Conference and Challenge Organizers: Gustavo Stolovitzky (chair), IBM Research Andrea Califano, Columbia University DREAM3 is part of a project we call the DREAM (Dialogue for Reverse Engineering Assessments and Methods) project. Its main objective is to catalyze the interaction between experiment and theory in the area of cellular network inference. The fundamental question for DREAM is simple: How can researchers assess how well they are describing the networks of interacting molecules that underlie biological systems, and how well can they predict the results of a biological experiment? The answer is not so simple. Researchers have used a variety of algorithms to deduce the structure of very different biological and artificial networks, and evaluated their success using various metrics. What is still needed, and what DREAM aims to achieve, is a fair comparison of the strengths and weaknesses of the methods and a clear sense of the reliability of the network models they produce. -- Tom Michoel <http://www.psb.ugent.be/~tomic/>