Is this paper interesting for you? Cheers, Roeland ------------------------------------------------------------------------------ ------------------------------------------------------------------------------ send mail only to q-bio@arXiv.org, do not reply to no-reply@... send any complaints regarding submissions directly to submitter. use a single `get' to request multiple papers, `list macros' for available macro packages, and `help' for a list of available commands and other info. ------------------------------------------------------------------------------ point your www client at http://arXiv.org/ To unsubscribe, e-mail To: q-bio@arXiv.org, Subject: cancel ------------------------------------------------------------------------------ Submissions to: Molecular Networks received from Wed 19 Apr 06 20:00:03 GMT to Thu 20 Apr 06 20:00:03 GMT ------------------------------------------------------------------------------ ------------------------------------------------------------------------------ \\ Paper: q-bio.MN/0604026 Date: Thu, 20 Apr 2006 12:18:25 GMT (78kb) Title: Alignment of biological networks Authors: Johannes Berg and Michael L\"assig Comments: 10 pages, 7 figures, 1 colour figure. Supporting text is available from the authors Subj-class: Molecular Networks; Genomics \\ Complex interactions between genes or proteins contribute a substantial part to phenotypic evolution. Here we develop an evolutionarily grounded method for the cross-species analysis of interaction networks by {\em alignment}, which maps bona fide functional relationships between genes in different organisms. Network alignment is based on a scoring function measuring mutual similarities between networks in their interaction patterns as well as sequence similarities between their nodes. High-scoring alignments as well as optimal alignment parameters are inferred by a systematic Bayesian analysis. We apply this method to analyze the evolution of co-expression networks between human and mouse. We find evidence for significant conservation of gene expression clusters and give network-based predictions of gene function. We discuss examples where cross-species functional relationships between genes do not concur with sequence similarity. \\ ( http://arXiv.org/abs/q-bio/0604026 , 78kb) %-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%-%- %%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%%--%% %%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%---%%%--- -- Roeland Merks Department of Plant Systems Biology VIB / Ghent University Technologiepark 927 B-9052 Ghent, Belgium http://www.psb.ugent.be Tel. +32-(0)9-33 13825 email: post@roelandmerks.nl http://www.roelandmerks.nl weblog: http://biolog.volkskrantblog.nl