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From: Gustavo Stolovitzky <gustavo@us.ibm.com> Date: Sun 23 May 2010 07:19:48 GMT+02:00 To: DREAM N-Z <DREAM_N-Z%IBMUS@us.ibm.com> Subject: DREAM5 Systems Biology Prediction Challenges

PLEASE LET ME KNOW IF YOU PREFER NOT TO RECEIVE ANNOUNCEMENTS FROM THE DREAM PROJECT SINCERE APOLOGIES IF YOU RECEIVE THIS ANNOUNCEMENT MORE THAN ONCE

Call for Systems Biology Predictions DREAM5: The 5th DIALOGUE ON REVERSE ENGINEERING ASSESSMENT AND METHODS

Dear Colleague,

We would like to invite you to participate in the following DREAM5 challenges

1. Epitope-Antibody Recognition (EAR) Challenge - Predict the binding specificity of peptide-antibody interactions. 2. TF-DNA Motif Recognition Challenge - Predict the specificity of a Transcription Factor binding to a 35-mer probe.

These are two of the four challenges that we will be having this year. The remaining two challenges

3. Systems Genetics Challenge - Predict disease phenotypes and infer gene networks from Systems Genetics data 4. Network Inference Challenge -Infer simulated and in-vivo gene regulatory networks.

will be posted in our website shortly.

To access the data sets, and descriptions of the DREAM5 challenges, please go to http://wiki.c2b2.columbia.edu/dream/index.php/ Challenges . The best performers in these challenges will be invited to present in the joint RECOMB Systems Biology/Regulatory Genomics/DREAM5 conference. See http://recombsat.c2b2.columbia.edu/ for details on this conference.

To learn more about the DREAM project, please go to http://wiki.c2b2.columbia.edu/dream/index.php/The_DREAM_Project

DREAM5 Challenge Submission Timeline Late May, 2010 Call for participation in the challenges. Challenges posted. September 20, 2010 Predictions Submission Deadline. Nov 16-20, 2010 RECOMB Systems Biology/Regulatory Genomics/ DREAM5 conference. (The DREAM5 conference track is on November 16th.)

Sincerely,

DREAM5 Challenge Organizers: Gustavo Stolovitzky (chair), IBM Research Robert J Prill, IBM Research Julio Saez Rodriguez, Sys Bio Dept, Harvard University.

DREAM5 is part of a project we call the DREAM (Dialogue for Reverse Engineering Assessments and Methods) project. Its main objective is to catalyze the interaction between experiment and theory in the area of rigorous assessment of systems biology prediction methods.

-- Tom Michoel <http://www.psb.ugent.be/~tomic/>