'total loss' vrees ik ... ;-)

-------- Original Message --------
Subject: density
Date: Fri, 11 Jun 2010 12:15:49 +0200
From: Stephane Rombauts <strom@psb.vib-ugent.be>
To: research@psb.ugent.be


Dear all,

I'm looking for away to measure the density of a biopolymer lighter than 0.00001g.
I could of course collect enough of this polymer to get a mass > 0.0001g, and submerge it then in water to measure the volume via water displacement...
But then I would need a LOT of material. And given it is not necessarily easy to get the pure material in large quantities, any other way would be welcome. One option could be a CsCl column and centrifuge it with the biopolymer as was done some time ago to purify DNA
(isopycnic centrifugation).
The problem there is that I have no way of labeling the polymer to be able to see where in the column the polymer ends up and as I will need a density ladder, the measurement will remain approximative.

Alternatively, if you know a (UGent/VIB) department that has a machine that does it all and is sensitive enough, let me know.

best regards
Stephane

-- 
==============================================================
Lieven Sterck, PhD

Tel:+32 (0)9 3313821                       Fax:+32 (0)9 3313809
VIB Department of Plant Systems Biology, UGent
Bioinformatics and Evolutionary Genomics Division
Technologiepark 927,         B-9052 Gent,             Belgium
Email: lieven.sterck@psb.vib-ugent.be
Website: http://bioinformatics.psb.ugent.be

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