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April 2024

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You are invited to attend “Single-cell driven enhancer modelling and design” ON April 30, 2024
by Delphine Verspeel 29 Apr '24

29 Apr '24

You are receiving this e-mail because you subscribed to our seminars announcements and reminders service at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | https://maillist.psb.ugent.be/mailman/listinfo/seminars ] . '' Single-cell driven enhancer modelling and design '' Prof Stein Aerts VIB Center for AI & Computational Biology KU Leuven BELGIUM Tuesday, April 30, 2024 11:00 am The combination of scRNA-seq and scATAC-seq allows building gene-regulatory atlases of any tissue and species. I will present several new computational strategies that exploit single-cell multi-omics data: (1) to model genomic enhancers using topic modelling and convolutional neural networks; and (2) to derive “enhancer-GRNs” (eGRN) with key transcription factors, genomic enhancers, and predicted target genes per cell type. I will discuss the results of several case studies where we applied these strategies, including the Drosophila brain, human melanoma, the mouse liver, and the evolution of cell types in the vertebrate telencephalon. Finally, I will discuss how enhancer models based on deep learning can be exploited to design synthetic enhancers for Drosophila and human cell types. Jozef Schell seminar room Technologiepark 71 - 9052 Invited by Prof Yves Van de Peer, P rof Dr Em Dirk Inz é and Prof Bart Lambrecht If you do not wish to receive this information anymore, please unsubscribe from future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | https://maillist.psb.ugent.be/mailman/listinfo/seminars ] Genome editing, cutting-edge technology for a sustainable agriculture VIB-UGent Center for Plant Systems Biology Ghent University Technologiepark-Zwijnaarde 71 9052 Ghent-Belgium Phone: +32(0)9 331 38 00 [ http://www.psb.vib-ugent.be/ | https://www.psb.ugent.be/ ]

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You are invited to attend “Control of plant phosphate homeostasis by inositol pyrophosphate nutrient messengers” ON March 7, 2024
by Delphine Verspeel 10 Apr '24

10 Apr '24

You are receiving this e-mail because you subscribed to our seminars announcements and reminders service at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | https://maillist.psb.ugent.be/mailman/listinfo/seminars ] . '' Control of plant phosphate homeostasis by inositol pyrophosphate nutrient messengers '' Prof Michael Hothorn Department of Plant Sciences Faculty of Science Science III University of Geneva SWITZERLAND Thursday, March 7, 2024 11:00 Phosphorus forms an essential structural component of membranes and nucleic acids, represents an important signaling molecule and the energy currency of the cell. It is taken up by plants in the form of inorganic phosphate (Pi). How eukaryotic cells ‘measure’ intracellular Pi levels and respond to changes in Pi availability remains to be uncovered at the mechanistic level. We have previously reported that eukaryotic SPX domains are cellular receptors for Pi-rich inositol pyrophosphate (PP-InsP) nutrient messengers. In Pi sufficient growth conditions, PP-InsP levels are high and enable the binding of the nutrient messenger to its SPX receptor. In plants, the activated receptor can in turn bind a family of phosphate starvation responsive transcription factors rendering them unable to bind DNA. Under phosphate starvation PP-InsP levels drop, the receptor – transcription factor complex dissociates and the released transcription factor can activate Pi-starvation responsive gene expression. I will present our current mechanistic understanding of this nutrient signaling pathway as well as a quantitative biochemical, structural and physiological characterization of PP-InsP biosynthesis and catabolism in the model plants Arabidopsis and Marchantia. Jozef Schell seminar room Technologiepark 71 - 9052 Invited by Prof Yves Van de Peer and Prof Jenny Russinova If you do not wish to receive this information anymore, please unsubscribe from future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | https://maillist.psb.ugent.be/mailman/listinfo/seminars ] Genome editing, cutting-edge technology for a sustainable agriculture VIB-UGent Center for Plant Systems Biology Ghent University Technologiepark-Zwijnaarde 71 9052 Ghent-Belgium Phone: +32(0)9 331 38 00 [ http://www.psb.vib-ugent.be/ | https://www.psb.ugent.be/ ]

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