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September 2024

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Fwd: PSB Seminar From redox signalling to iron sulfur metabolism and back - CANCELLED
by Eline De Winter 23 Sep '24

23 Sep '24

Eline De Winter - Administrative assistant Administrative Support VIB-UGent Center for Plant Systems Biology Ghent University Technologiepark-Zwijnaarde 71 - 9052 Ghent - Belgium Tel. +32(0)9 331 39 99 [ http://www.psb.ugent.be/ | www.psb.ugent.be ] Genome editing, cutting-edge technology for a sustainable agriculture > From: "seminar" <seminar(a)psb.vib-ugent.be> > To: "meetings" <meetings(a)psb.vib-ugent.be> > Sent: Monday, September 2, 2024 3:15:15 PM > Subject: PSB Seminar From redox signalling to iron sulfur metabolism and back > | PSB Seminar > From redox signalling to iron sulfur metabolism and back > Prof Andreas Meyer > Rheinische Friedrich-Wilhelms-Universität Bonn > Germany > Where: > When: 26-SEP-2024@11:00 > Invited by Yves Van de Peer > Stress-related responses and several developmental processes in plants are > accompanied by the formation of reactive oxygen species (ROS) and subsequent > translation of this primary oxidation to changes in protein thiol oxidation as > a key step in stress signalling pathways. To understand signalling mechanisms, > one key feature that needs to be understood is the dynamics of the respective > redox changes in time and space. The use of genetically encoded probes for H2O2 > and the glutathione redox potential (EGSH) over the past two decades has > provided access to the respective physiological parameters in live cells. > Genetic dissection of dynamic changes in these parameters including production > and transmission systems, allows in vivo testing of hypotheses for protein > functions derived from in vitro studies. Glutaredoxins (GRXs) are generally > considered key elements for the transmission of redox signals from the local > EGSH to protein thiols. Yet, despite a largely conserved overall structure, a > second subgroup of GRXs does not function as oxidoreductases but rather acts in > iron-sulfur cluster transfer. Beyond addressing the role of GRXs in redox > signalling, I will also present our recent work on the mitochondrial > iron-sulfur cluster assembly and transfer machinery, which provides new > insights into the flux of iron-sulfur clusters and a key role of lipoyl > synthase. Alterations in the mitochondrial lipoylation system not only affect > mitochondrial metabolism, but may also lead back to cellular redox signalling. > [ https://twitter.com/psb_vib ] > If you do not wish to receive this information anymore, please unsubscribe from > future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | > https://maillist.psb.ugent.be/mailman/listinfo/seminars ]

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