- Seminars - maillist.psb.ugent.be

Seminar on Pectin Acetylation - Cezary Waszczak
by Frank Van Breusegem 18 Jun '25

18 Jun '25

Dear all, On July 1st (11AM-noon), at the occasion of the closed PhD defense of Zeya Chen, we're organising a Meet the Expert session (supported by the UGent Doctoral Schools) with dr. Cezary Waszcak. See Seminar anouncement in attach. There will also be a sandwich lunch for PhD students and post-docs after the seminar. In addition, one on one meetings can be organised on June 30th and July 1st. Cezary is an alumnus PhD student from our department and is now independent group leader at the University of Helsinki. Have a sunny weekend, Frank and Jingjing Prof. dr. Frank Van Breusegem - Group Leader Oxidative Stress Signaling - www.vanbreusegemlab.be UGent Department of Plant Biotechnology and Bioinformatics VIB Center of Plant Systems Biology Technologiepark 71, 9052 Gent, BELGIUM [ http://www.psb.ugent.be/ | www.psb.ugent.be ]

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Fwd: PSB Seminar TODAY@11:00H in the Jozef Schell seminar room: Glutathione metabolism and its implications for growth
by Eline De Winter 12 Jun '25

12 Jun '25

Eline De Winter - Administrative assistant Administrative Support VIB-UGent Center for Plant Systems Biology Ghent University Technologiepark-Zwijnaarde 71 - 9052 Ghent - Belgium Tel. +32(0)9 331 39 99 [ http://www.psb.ugent.be/ | www.psb.ugent.be ] Genome editing, cutting-edge technology for a sustainable agriculture > From: "seminar" <seminar(a)psb.vib-ugent.be> > To: "meetings" <meetings(a)psb.vib-ugent.be> > Sent: Thursday, June 12, 2025 8:05:01 AM > Subject: PSB Seminar TODAY@11:00H : Glutathione metabolism and its implications > for growth > | PSB Seminar > TODAY@11:00H : Glutathione metabolism and its implications for growth > Andreas Meyer > Universität Bonn > Germany > Where: Jozef Shell Seminar room - VIB-UGent Center for Plant Systems Biology > Ghent University > Technologiepark 71 - 9052 Ghent - Belgium > Tel. +32(0)9 331 38 00 > [ http://www.psb.ugent.be/ | www.psb.ugent.be ] > When: 12-JUN-2025@11:00 > Invited by Yves Van de Peer , Frank Van Breusegem > Glutathione was among the first metabolites cells invented for defence against > the destructive power of reactive oxygen when the oxygen concentration on Earth > started to rise during the great oxygenation event approximately 2.4 billion > years ago. In addition to detoxifying reactive oxygen species, glutathione now > has a wide range of other functions, including redox control and redox > signalling, detoxifying electrophilic compounds, acting as a cofactor in > metabolic reactions and donating sulfur donor for synthesising > sulfur-containing metabolites. The developmental arrest observed in > glutathione-deficient Arabidopsis mutants suggests a potential connection > between glutathione and meristematic activity. However, our understanding of > the impact of glutathione metabolism on growth remains limited. > In order to understand redox signalling mechanisms, the dynamics of the > respective redox changes must be understood in terms of both time and space. > Over the past two decades, the use of genetically encoded probes for H2O2 and > the glutathione redox potential (EGSH) has provided access to the respective > physiological parameters in live cells. In combination with genetic approaches, > they allow the genetic dissection of production and transmission systems in > vivo. The talk will address various glutathione-dependent processes, focussing > particularly on those mediated by glutaredoxins, and will discuss our current > understanding of how glutathione affects growth in Arabidopsis. > Jozef Shell Seminar room - VIB-UGent Center for Plant Systems Biology > Ghent University > Technologiepark 71 - 9052 Ghent - Belgium > Tel. +32(0)9 331 38 00 > [ http://www.psb.ugent.be/ | www.psb.ugent.be ] > [ https://twitter.com/psb_vib ] > If you do not wish to receive this information anymore, please unsubscribe from > future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | > https://maillist.psb.ugent.be/mailman/listinfo/seminars ]

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Re: [Seminars] PSB Seminar Towards the identification of novel metal- or thiol-based mechanisms in plants via the biochemical characterization of TRX-like proteins
by Luna VANNIEUWKERKE 19 Mar '25

19 Mar '25

Hey, Ik heb in 'attach' een banner gestoken en er is mij gevraagd geweest deze mee uit te zenden bij de aankondiging. Is dat mogelijk? Groetjes, Luna > From: "seminar" <seminar(a)psb.vib-ugent.be> > To: meetings(a)psb.vib-ugent.be > Sent: Wednesday, March 19, 2025 8:35:55 AM > Subject: PSB Seminar Towards the identification of novel metal- or thiol-based > mechanisms in plants via the biochemical characterization of TRX-like proteins > | PSB Seminar > Towards the identification of novel metal- or thiol-based mechanisms in plants > via the biochemical characterization of TRX-like proteins > Nicolas Rouhier > Université de Lorraine > France > Where: Jozef Shell Seminar room - VIB-UGent Center for Plant Systems Biology > Ghent University > Technologiepark 71 - 9052 Ghent - Belgium > Tel. +32(0)9 331 38 00 > [ http://www.psb.ugent.be/ | www.psb.ugent.be ] > When: 03-APR-2025@11:00 > Invited by Yves Van de Peer , Frank Van Breusegem > Photosynthetic organisms have a high diversity of proteins belonging to the > thioredoxin (TRX) superfamily. It comprises more than 150 proteins distributed > in different families and classes, including in particular thioredoxins, > glutaredoxins, protein disulfide isomerases, thiol peroxidases or glutathione > transferases, which share the TRX structural fold. Many of them have one or two > redox-active cysteines and a characteristic cis-proline at specific positions, > but also additional domains or secondary structures at either end or inserted > into the protein core. With the aim of further describing the TRX superfamily > in plants, we identified a set of 17 atypical TRX-like proteins from > Arabidopsis thaliana, which have not been considered before. The in silico > analyses revealed that they differ by their active-site signature and > structural features and that they are spread in eight distinct classes. To > delineate the possible functions of these novel TRX-like proteins, we combined > biochemical and structural analyses of recombinant proteins together with > cellular approaches to determine their subcellular localizations. Recent data > obtained on specific representatives will be presented. > Jozef Shell Seminar room - VIB-UGent Center for Plant Systems Biology > Ghent University > Technologiepark 71 - 9052 Ghent - Belgium > Tel. +32(0)9 331 38 00 > [ http://www.psb.ugent.be/ | www.psb.ugent.be ] > [ https://twitter.com/psb_vib ] > If you do not wish to receive this information anymore, please unsubscribe from > future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | > https://maillist.psb.ugent.be/mailman/listinfo/seminars ]

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Fwd: Special Solvay Institutes Scholar seminar-- Alexis Komor Nov 6, 11am
by Eline De Winter 21 Oct '24

21 Oct '24

> From: "Thomas Jacobs" <thomas.jacobs(a)psb.vib-ugent.be> > To: "research" <research(a)psb.vib-ugent.be> > Cc: "seminar" <seminar(a)psb.vib-ugent.be> > Sent: Monday, October 21, 2024 10:16:22 AM > Subject: Re: Special Solvay Institutes Scholar seminar-- Alexis Komor Nov 6 > Dear all, > Just a reminder about the special seminar on November 6. Please see the attached > flyer. > cheers, > Tom > ----- On 7 Oct, 2024, at 09:23, Thomas Jacobs <thomas.jacobs(a)psb.ugent.be> > wrote: > Dear all, > On November 6, Alexis Komor will be visiting VIB-UGent as part of the > prestigious Solvay Institutes New Horizons Lectures in chemistry > http://www.solvayinstitutes.be/html/new_horizons.html . Alexis is probably best > known for her development of CRISPR Base Editing technology during her postdoc > in David Liu's lab at the Broad (more information below). I am currently > putting the program together and are looking for any PIs, postdocs or students > who would be interested to meet with her. If you are interested, please send me > an email. Students and postdocs, we will also arrange a lunch to meet and > discuss with Alexis. > More details on her research and talk below. > cheers, > Tom > Dr. Alexis Komor, Assistant Professor, UCSD > Title: Engineering and Evolving Nucleic Acid Modifying Enzymes > Base editors (BEs) are comprised of a catalytically inactivated Cas9 (dCas9 or > Cas9n) tethered to a single-stranded DNA (ssDNA) modifying enzyme, which > directly chemically modifies target nucleobases within a “base editing window”. > Two classes of base editors exist, which use cytosine and adenine deamination > chemistries to catalyze the conversion of C•G base pairs to T•A (CBEs), and A•T > base pairs to G•C (ABEs), respectively. These transition mutations > (purine-purine or pyrimidine-pyrimidine) are mediated by uracil (cytosine > deamination) or inosine (adenine deamination) intermediates, and occur with > high efficiencies (up to 90% conversion) with little to no competing indel > formation. Expansion of the BE toolbox to include transversion editors will > require engineering of new nucleic acid editing enzymes. As ABEs were developed > by engineering and evolving a tRNA adenosine deaminase enzyme, TadA, into a > ssDNA adenosine deaminase enzyme, TadA7.10, the development of future BEs may > be accomplished by converting additional tRNA modifying enzymes into ssDNA > editing enzymes. In this talk I will describe my lab’s efforts to > mechanistically understand how current BE enzymes function. The enhanced > understanding of how known DNA editing enzymes function, and in particular how > wtTadA was converted into TadA7.10, can inform the development of future DNA > editing enzymes. > Background > The Komor lab focuses on four main research programs: 1, Development Of New > Precision Genome Editing Methodologies; 2, Mechanistic Characterization Of > Nucleic Acid Editing Enzymes; 3, Mechanistic Understanding Of Cellular > Processing Of Genome Editing Intermediates; and 4, Clinical Characterization Of > Human Genetic Variants. > Alexis received her B. S. degree in chemistry from the University of California, > Berkeley in December of 2008. She then joined the lab of Jacqueline K. Barton > at the California Institute of Technology for her doctoral studies. While at > Caltech, she worked as an NSF Graduate Research Fellow on the design, > synthesis, and study of DNA mismatch-binding metal complexes and received her > Ph.D. in 2014. She pursued postdoctoral work as a Ruth L. Kirschstein NIH > Postdoctoral Fellow in the laboratory of David R. Liu, where she developed base > editing, a new approach to genome editing that enables the direct, irreversible > chemical conversion of one target DNA base into another in a programmable > manner, without requiring double-stranded DNA backbone cleavage. Alexis joined > the Department of Chemistry and Biochemistry at the University of California at > San Diego in 2017, where her lab develops and applies new precision genome > editing techniques to the functional genomics field. Alexis’s contributions in > teaching, mentoring, and research have been recognized through many awards, > including the Cottrell Scholar Award, the “Talented 12” recognition by C&EN > News, an NSF Faculty Early Career Development (CAREER) award, an NIH early > stage investigator Maximizing Investigators’ Research Award (MIRA), and a “40 > under 40” recognition in healthcare by Fortune Magazine. > Thomas Jacobs - Group leader > Plant Genome Editing > VIB-UGent Center for Plant Systems Biology > Ghent University > Technologiepark-Zwijnaarde 71 - 9052 Ghent - Belgium > Tel. +32(0)9 331 38 60 > [ http://www.psb.ugent.be/ | www.psb.ugent.be ] > Genome editing, cutting-edge technology for a sustainable agriculture

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Fwd: PSB Seminar From redox signalling to iron sulfur metabolism and back - CANCELLED
by Eline De Winter 23 Sep '24

23 Sep '24

Eline De Winter - Administrative assistant Administrative Support VIB-UGent Center for Plant Systems Biology Ghent University Technologiepark-Zwijnaarde 71 - 9052 Ghent - Belgium Tel. +32(0)9 331 39 99 [ http://www.psb.ugent.be/ | www.psb.ugent.be ] Genome editing, cutting-edge technology for a sustainable agriculture > From: "seminar" <seminar(a)psb.vib-ugent.be> > To: "meetings" <meetings(a)psb.vib-ugent.be> > Sent: Monday, September 2, 2024 3:15:15 PM > Subject: PSB Seminar From redox signalling to iron sulfur metabolism and back > | PSB Seminar > From redox signalling to iron sulfur metabolism and back > Prof Andreas Meyer > Rheinische Friedrich-Wilhelms-Universität Bonn > Germany > Where: > When: 26-SEP-2024@11:00 > Invited by Yves Van de Peer > Stress-related responses and several developmental processes in plants are > accompanied by the formation of reactive oxygen species (ROS) and subsequent > translation of this primary oxidation to changes in protein thiol oxidation as > a key step in stress signalling pathways. To understand signalling mechanisms, > one key feature that needs to be understood is the dynamics of the respective > redox changes in time and space. The use of genetically encoded probes for H2O2 > and the glutathione redox potential (EGSH) over the past two decades has > provided access to the respective physiological parameters in live cells. > Genetic dissection of dynamic changes in these parameters including production > and transmission systems, allows in vivo testing of hypotheses for protein > functions derived from in vitro studies. Glutaredoxins (GRXs) are generally > considered key elements for the transmission of redox signals from the local > EGSH to protein thiols. Yet, despite a largely conserved overall structure, a > second subgroup of GRXs does not function as oxidoreductases but rather acts in > iron-sulfur cluster transfer. Beyond addressing the role of GRXs in redox > signalling, I will also present our recent work on the mitochondrial > iron-sulfur cluster assembly and transfer machinery, which provides new > insights into the flux of iron-sulfur clusters and a key role of lipoyl > synthase. Alterations in the mitochondrial lipoylation system not only affect > mitochondrial metabolism, but may also lead back to cellular redox signalling. > [ https://twitter.com/psb_vib ] > If you do not wish to receive this information anymore, please unsubscribe from > future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | > https://maillist.psb.ugent.be/mailman/listinfo/seminars ]

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PSB Seminar invitation: Cell wall charge in roots and its role in nutrient acquisition.
by seminars＠psb.vib-ugent.be 28 Jun '24

28 Jun '24

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PSB Seminar invitation: MOLECULAR PHENOLOGY: IN NATURA RESPONSES OF PLANTS TO A SEASONAL ENVIRONMENT
by seminars＠psb.vib-ugent.be 28 Jun '24

28 Jun '24

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PSB Seminar invitation: MPK4 Governs Plant Cell Cycle by Negative Regulation of APCCCS52B Complex Activity
by seminars＠psb.vib-ugent.be 28 Jun '24

28 Jun '24

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PSB Seminar invitation: Cell wall charge in roots and its role in nutrient acquisition.
by seminars＠psb.vib-ugent.be 26 Jun '24

26 Jun '24

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PSB Seminar invitation: MOLECULAR PHENOLOGY: IN NATURA RESPONSES OF PLANTS TO A SEASONAL ENVIRONMENT
by seminars＠psb.vib-ugent.be 26 Jun '24

26 Jun '24

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