Calendar Name:	seminars
Scheduled for:	Thursday, February 14 2013, 11:00 - 12:30
Event text:	Prof Charles White G?n?tique, Reproduction et D?veloppement UMR CNRS 6293 - Clermont Universit? - INSERM U1103 Campus des C?zeaux Universit? Blaise Pascal Clermont Ferrand FRANCE
Details:	?Roles and mechanisms of recombination in meiosis and mitosis? ABSTRACT O. Da Ines, S. Amiard, C. Charbonnel, K. Abe, F. Degroote, H. Serra, I. Mestiri, C. Goubely, E. Allain, M.E. Gallego and Charles I. White Working with Arabidopsis thaliana, we are studying the roles and mechanisms of genetic recombination - indispensable to the maintenance of genome integrity and an essential source of genetic diversity. Recombination acts to repair DNA damage and in particular, DNA double-strand breaks (DSB). In addition to arising by accident (replication, radiation, mutagens ... ), DSB are naturally present at the ends of linear eukaryotic chromosomes (telomeres) and also produced in a programmed manner in order to induce recombination and genetic exchange (meiosis). DSB are efficiently repaired through multiple individual pathways of homologous or non-homologous recombination and although knowledge of recombination mechanisms has considerably advanced, the complex interrelationships and regulation of these pathways are far from being fully understood. A particularly striking example of the danger of inappropriate recombination is seen in the severe karyotypic and genomic instability in the presence of telomere dysfunction. Current knowledge of roles and mechanisms of recombination in plants will be presented through discussion of our recent results on somatic recombination pathways, responses to telomere dysfunction and the differing requirements for proteins of the Rad51 family in pairing of meiotic centromeric regions and chromosome arms. ? Da Ines, O., Abe, K., Goubely, C., Gallego, M. E., & White, C. I. (2012). Differing Requirements for RAD51 and DMC1 in Meiotic Pairing of Centromeres and Chromosome Arms in Arabidopsis thaliana. PLoS Genetics, 8(4), e1002636. ? Wei Wei, Zhaoqing Ba, Min Gao, Yang Wu, Yanting Ma, Simon Amiard, Charles I. White, Jannie Michaela Rendtlew Danielsen, Yun-Gui Yang and Yijun Qi. (2012). A Role for Small RNAs in DNA Double-Strand Break Repair. Cell 149: 101-112 ? Amiard S, Depeiges A, Allain E, White CI, Gallego ME (2011) Arabidopsis ATM and ATR Kinases Prevent Propagation of Genome Damage Caused by Telomere Dysfunction. Plant Cell, 23:4254-65. ? C. Charbonnel, E. Allain, M.E. Gallego and C. White. (2011). Kinetic analysis of post-replicative DSB repair pathways in Arabidopsis. DNA Repair, 10:611-619.