Calendar Name:	seminars
Scheduled for:	Monday, November 28 2011, 11:00 - 12:30
Event text:	Prof Natasha Raikhel Center for Plant Cell Biology & the Institute for Integrative Genome Biology Department of Botany and Plant Sciences University of California Riverside USA
Details:	?Chemical Biology:Towards a Systems View of the Endomembrane system? ABSTRACT Although it is known that proteins are delivered to and recycled from the plasma membrane (PM) via endosomes, the nature of the compartments and pathways responsible for cargo and vesicle sorting and cellular signaling is poorly understood. Such highly dynamic processes are not easily approached genetically. To define and dissect specific recycling pathways, rapid-acting chemical affecters of proteins involved in vesicle trafficking, especially through endosomes, would be invaluable. Thus, we identified chemicals affecting essential steps in PM/endosome trafficking by utilizing the intensely localized PM transport at the tips of germinating tobacco pollen tubes. We screened diverse chemical libraries for those that interfered with pollen germination and tip growth. We found that many also had effects in Arabidopsis roots for which there are several well-characterized marker proteins that cycle to and from the plasma membrane. Recent results from our screens will be discussed.