You are receiving this e-mail because you subscribed to our seminars announcements and reminders service at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | https://maillist.psb.ugent.be/mailman/listinfo/seminars ] . '' Single-cell driven enhancer modelling and design '' Prof Stein Aerts VIB Center for AI & Computational Biology KU Leuven BELGIUM Tuesday, April 30, 2024 11:00 am The combination of scRNA-seq and scATAC-seq allows building gene-regulatory atlases of any tissue and species. I will present several new computational strategies that exploit single-cell multi-omics data: (1) to model genomic enhancers using topic modelling and convolutional neural networks; and (2) to derive “enhancer-GRNs” (eGRN) with key transcription factors, genomic enhancers, and predicted target genes per cell type. I will discuss the results of several case studies where we applied these strategies, including the Drosophila brain, human melanoma, the mouse liver, and the evolution of cell types in the vertebrate telencephalon. Finally, I will discuss how enhancer models based on deep learning can be exploited to design synthetic enhancers for Drosophila and human cell types. Jozef Schell seminar room Technologiepark 71 - 9052 Invited by Prof Yves Van de Peer, P rof Dr Em Dirk Inz é and Prof Bart Lambrecht If you do not wish to receive this information anymore, please unsubscribe from future mailings at [ https://maillist.psb.ugent.be/mailman/listinfo/seminars | https://maillist.psb.ugent.be/mailman/listinfo/seminars ] Genome editing, cutting-edge technology for a sustainable agriculture VIB-UGent Center for Plant Systems Biology Ghent University Technologiepark-Zwijnaarde 71 9052 Ghent-Belgium Phone: +32(0)9 331 38 00 [ http://www.psb.vib-ugent.be/ | https://www.psb.ugent.be/ ]
