[BBC] [Gtpb] Fwd: ANNOUNCEMENT: HPND12 - "Hunting for Promoters" Bioinformatics Training Course
Pedro Fernandes
pfern at igc.gulbenkian.pt
Thu Sep 20 21:18:49 CEST 2012
ANNOUNCEMENT
HPND12 - Hunting for Promoters with NGS data
with Alexander Kel, Martin Enge and Chritian Zinser
Course description:
This course is set-up to review the basic principles of gene
regulation, first of all, by prediction of promoters and distant
enhancers and silencers and by analysis of structure of the gene
regulatory regions and identification of binding sites for
transcription factors. The most intriguing parts of genomes, still
hiding from clear understanding, are the gene regulatory regions --
promoters and enhancers. Analysis and prediction of the regulatory
sites in the genome, which is now a hot topic as a result of the
growth of the number of newly sequenced genomes, and the result of
high throughput sequencing methodologies becoming commonplace. Also,
the introduction of high throughput-sequencing based techniques for
genome-wide epigenetic analysis such as ChIP-seq has revolutionized
our ways for studying the gene regulatory mechanisms. of First of all,
effective and robust methods for annotation of new genomes are
urgently needed now.But also, recognition and analysis of these areas
in the new and existing genomes becomes one of the most important
parts of understanding the mechanisms of genome functioning. In this
course, the attendees will learn several techniques of finding
promoters and enhancers and the principles on which these methods are
based. Through "hands on" exercises, several analytical tools will be
displayed and the results citicized in the light of assessing their
reliability and the possibilities that they open of assigning gene
function based on automatic prediction. Also, the course will include
an overview of the state of the art in lab techniques for studying
gene regulation as well as a detailed account of data analysis for the
more commonly used techniques such as ChIP-seq.
Objectives
The course will consist of lectures that lay out the conceptual
framework as needed and and "hands on" exercises will provide the
practical insight on the use of the methods, gradually, in order to
produce skills that can be used with a relatively high degree of
independence. Participants will know how to set-up some of the
programs, and use publicly available servers for more complex
analytical jobs, in an informed fashion, so that they fully understand
the output generated and how its quality can be assessed. Participants
will also learn the novel principles of organization of gene
regulatory regions, which will help them to interpret their results of
genomics and transcriptomics studies.
Target Audience:
The course is directed to researchers in biology, bioinformatics,
biochemistry and medicine. Background knowledge in elementary
bioinformatics is not absolutely necessary, but can be very useful.
Please note that the PathProt brainstorming event takes place on the
week just before this course. You will need to register in PathProt
separately, though. Please use its specific PathProt website
Course Pre-requisites:
Basic biochemistry. Elementary computing skills
Futher details, including application instructions available at
http://gtpb.igc.gulbenkian.pt/bicourses/HPND12
thank you for your interest
Pedro Fernandes
--
Pedro Fernandes
GTPB Coordinator
Instituto Gulbenkian de Ciência
Apartado 14
2781-901 OEIRAS
Tel +351 21 4407912
http://gtpb.igc.gulbenkian.pt
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