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<p class=MsoNormal style='margin-bottom:7.5pt'><b><span style='font-size:10.0pt;
font-family:"Verdana","sans-serif";color:#222222'>Structural Bioinformatician
(M/F) – Postdoc position – 3 years<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-bottom:7.5pt'><span style='font-size:10.0pt;
font-family:"Verdana","sans-serif";color:#222222'>The 3D structure-function
group, within the department of Biochemistry at the Cardiovascular Research
Institute Maastricht (Maastricht University), a small and newly started unit,
is seeking a Structural Bioinformatician to start in October 2007 or shortly
thereafter.<o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>The group has a broad interest in the structure-function studies
of coagulation proteins that are involved is homeostasis as well as in many
pathological conditions such as thromboembolism and bleeding. Central to the
research is the information exchange between experimental (i.e. basic
biochemical/molecular biology/peptide chemistry/surface plasmon resonance) and
computational approaches (docking/molecular modeling/virtual ligand screening)
such that new information on the function of these essential proteins can be
obtained, which ultimately will lead to improved treatment regimes, diagnostics
as well as novel therapeutics in the cardiovascular field.<o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>The ideal candidate will have a background in de biological,
biochemical or medical sciences with a strong track record in computer science
and will be experienced in the use of molecular modeling packages, docking
approaches and virtual ligand screening in both a WINDOWS and a LINUX
environment.<o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>You will be responsible for the generation, processing, analysis
and storage of data generated, for system maintenance and drive the development
of new approaches to the common research objectives. You will be a team player,
with good social skills working in collaboration with Dr. Nicolaes as well as
with a PhD student. Our group has a close collaboration with the group of Dr.
B. Villoutreix (INSERM U648, Paris, France) in the field of structural
bioinformatics. Occasionally, depending on the results, your skills and
interests, your assistance in ‘wet biochemical experimentation’
will be called upon.<o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>A major focus of the research project is to identify and
characterize new small compounds that are directed against selected coagulation
proteins and that may be used as tools by the in vitro experimentalists, as
well as serve as starting compounds for the development of novel pro- or anticoagulant
drugs.<o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>Salary will be on approximately the University Grade 11-0,
(depending on skills and experience, gross salary of ~ € 40,000,
resulting in a net monthly salary of ~ 2000) + a maximum of € 4000 moving
Allowance.<o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>An evaluation will be made after 1 year and upon positive
outcome of the evaluation, the position will be extended for another 2 years. <o:p></o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:
7.5pt;margin-left:0cm'><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#222222'>You may send a CV, with the names and addresses of two referees
and a covering letter to Dr. G. Nicolaes, Department of Biochemistry,
Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER,
Maastricht, the Netherlands. Tel: +31-43-3881539, e-mail </span><a
href="mailto:g.nicolaes@bioch.unimaas.nl"><span style='font-size:10.0pt;
font-family:"Verdana","sans-serif"'>g.nicolaes@bioch.unimaas.nl</span></a><span
style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:#222222'><o:p></o:p></span></p>
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