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<div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 16px/normal 'Times New Roman'; min-height: 18px; "><br></div><p align="justify" style="margin: 0.0px 0.0px 13.0px 0.0px; text-align: justify"><font face="Arial" size="5" style="font: 17.0px Arial"><b>Postdoc computational chemistry/structural bioinformatics (2 yrs)</b></font></p><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: justify; line-height: 17px; "><font face="Verdana" size="3" style="font: 12.0px Verdana"><b>Project: Parametrisation of an all-atom force field with non-natural amino acids</b></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: justify; line-height: 17px; "><font face="Verdana" size="3" style="font: 12.0px Verdana">The laboratory has significant expertise in the development of empirical force fields predicting mutational changes in the free energy of folding or binding of proteins. The aim of the current project is to extend the capabilities of the force field towards non-natural amino acids. This work involves obtaining good estimates of atomic parameters such as volumes, charges, hydrophobicity and compound properties such as backbone and sidechain entropy, from datamining and first principle simulations. You will need a good understanding of the physicochemistry of organic compounds and their interaction with proteins. The candidate will have a strong background in computational chemistry or structural bioinformatics and experience with c++ programming will be considered a serious plus.</font></div><p align="justify" style="margin: 0.0px 0.0px 0.0px 0.0px; text-align: justify; line-height: 17.0px"><font face="Times New Roman" size="5" style="font: 16.0px Times New Roman"> </font></p><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: justify; line-height: 17px; "><font face="Verdana" size="3" style="font: 12.0px Verdana">For more information contact Prof. Joost Schymkowitz (<a href="mailto:joost.schymkowitz@vub.ac.be"><font color="#0022ed" style="color: #0022ed"><u>joost.schymkowitz@vub.ac.be</u></font></a>)</font></div><p style="margin: 0.0px 0.0px 0.0px 0.0px"><font face="Times New Roman" size="5" style="font: 16.0px Times New Roman"> </font></p><p style="margin: 0.0px 0.0px 0.0px 0.0px"><font face="Helvetica" size="3" style="font: 11.0px Helvetica"> </font></p><p style="margin: 0.0px 0.0px 0.0px 0.0px"><font face="Times New Roman" size="3" style="font: 12.0px Times New Roman"> </font></p><div><span class="Apple-style-span" style="border-collapse: separate; 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