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<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal align=center style='text-align:center'><img width=575
height=98 id="Picture_x0020_1" src="cid:image001.jpg@01CA3235.7331CEE0"
alt=banner><o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal align=center style='text-align:center'><span lang=EN-US
style='font-size:16.0pt'>Postdoc positions in Comparative Genomics<o:p></o:p></span></p>
<p class=MsoNormal align=center style='text-align:center'><span lang=EN-US
style='font-size:14.0pt'><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US>The CMBI at the Nijmegen Center for
Molecular Life Sciences has two open positions for talented and motivated scientists
to do bioinformatics research into:</span><span lang=EN-US style='font-size:
12.0pt'><o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
lang=EN-US><span style='mso-list:Ignore'>1)<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><u><span lang=EN-US>Unraveling patterns behind
mental retardation:<o:p></o:p></span></u></p>
<p class=MsoNormal><span lang=EN-US>We have compiled a catalogue of more than
400 genes, mutations in which give rise to mental retardation. Several of these
genes have already been demonstrated to act together in molecular pathways.
However, the global biological coherence behind mental retardation genes is
unknown. The challenge is to address this, e.g. via analyzing protein-protein
interactions, via expression in specific tissues, via shared phenotypes in
human and model organisms and via their shared evolutionary origin. You will
query various types of genomics data, including proprietary gene-expression and
functional data in Drosophila, to uncover shared pathways. Your work will shed
light onto genetic design principles that underlie human brain function and
will identify new candidate genes for mental retardation. <o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
lang=EN-US><span style='mso-list:Ignore'>2)<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><u><span lang=EN-US>Evolutionary deconstruction
of the Ciliome: <o:p></o:p></span></u></p>
<p class=MsoNormal><span lang=EN-US>The cilium is a eukaryotic organelle whose
malfunction has been shown to be responsible for a wide array of genetic
diseases. Already the evolutionary analysis of known ciliary proteins and other
genomics data has successfully predicted new ciliary proteins. You will map the
origin and evolution of the ciliome among the eukaryotes to find new candidate
ciliary proteins, to detect sub-modules within the cilium and in general to
link the evolution of the cilium to its functions. <o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US>The projects combine the expertise of the
Huynen group in the analysis of genomics data to predict protein function with
the expertise in studying genetic disease of the groups of Annette Schenck and
Ronald Roepman (Human Genetics, Nijmegen Center for Molecular Life Sciences).
This collaboration ensures direct experimental testing of interesting newly
predicted candidate proteins and pathways. <o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US>The positions are initially for two years
with ample possibilities for extension. Requirements: You have PhD in
Bioinformatics or in Natural Sciences with a published affinity for large-scale
Bioinformatics analyses coupled to in depth study of biological systems.
Salary: starting at 40.458 – 46.695 Euro, depending on experience. <o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US>For more information please contact Martijn
Huynen (</span><a href="mailto:huynen@cmbi.ru.nl"><span lang=EN-US>huynen@cmbi.ru.nl</span></a><span
lang=EN-US>, www.cmbi.ru.nl). To apply, please e-mail a letter describing
research interests and past research activities, a CV, and the names of three
referees before October 15<sup>th </sup>, 2009.<o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US> <o:p></o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
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