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<div>The Biomolecular Mass Spectreometry and Proteomics Group at Utrecht University the Netherlands is looking for a PhD student or PostDoc in Bioinformatics</div>
<div>for the following;</div>
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<div><span style="text-align: justify; ">In this project we will develop novel proteomics technology to address proteome complexity in melanoma, which shows a rapid increase in incidence and is known for its aggressive nature in development of malignant metastasis
and therapeutic resistance. The oncogenic BRAF</span><font style="text-align: justify; "><sup>V600E</sup></font><span style="text-align: justify; "> protein kinase, which leads to activation of the RAS–RAF–MEK–ERK</span><i style="text-align: justify; "> </i><span style="text-align: justify; ">signaling
pathway, is frequently mutated in human cancer, including approximately 70% of malignant melanomas. In on-going collaborative efforts with the NKI we target the BRAF</span><font style="text-align: justify; "><sup>V600E </sup></font><span style="text-align: justify; ">proteome
using high throughput proteomics, focusing on a variety of posttranslational modifications (PTMs). Currently we are looking for a Bioinformatician to support these efforts. He/she will develop novel software tools that allow mining of the data for biological
relevant PTM-expression changes and potential ‘crosstalk’ between the different PTMs and the signaling networks involved.</span></div>
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<div style="text-align: justify;">For questions and/or application please mail,</div>
<div style="text-align: justify;"><a href="mailto:m.altelaar@uu.nl">m.altelaar@uu.nl</a> </div>
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<div>===========================</div>
<div>Maarten Altelaar</div>
<div>Assistant Professor</div>
<div>Biomolecular Mass Spectrometry</div>
<div>and Proteomics Group</div>
<div>Utrecht University</div>
<div>Padualaan 8, 3584 CH, Utrecht</div>
<div>The Netherlands</div>
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<div>E: <a href="mailto:m.altelaar@uu.nl">m.altelaar@uu.nl</a></div>
<div>W: <a href="http://www.hecklab.com">http://www.hecklab.com</a></div>
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