[Seminars] PSB event reminder

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Calendar Name: seminars
Scheduled for: Tuesday, December 7 2010, 10:00 - 11:00
Event text:    Klaas Vandepoele
	       
	       VIB, Dept. of Plant Systems Biology
	       Ghent University
	       
	       BELGIUM
Details:       "Transferring gene functions between different plant
	       species using PLAZA 2.0"
	       
	       ABSTRACT
	       PLAZA is an online comparative genomics platform where
	       data generated by different plant sequencing initiatives
	       is integrated and combined with advanced methods for
	       data mining. This resource includes structural and
	       functional annotation of published plant genomes
	       together with a large set of interactive tools to study
	       gene function and gene and genome evolution.
	       Pre-computed data sets cover homologous gene families,
	       multiple sequence alignments, phylogenetic trees,
	       intra-species whole-genome dot plots, and genomic
	       colinearity between species. The Workbench provides an
	       efficient environment to analyze user-defined gene sets
	       using PLAZA's interface including GO enrichment analysis
	       for all species.
	       The second release of this resource integrates
	       whole-genome information from 23 plants covering 11
	       dicots, 5 monocots, 2 (club-)mosses and 5 algae
	       (>840,000 genes stored in >22,000 multi-species gene
	       families). New features include functional gene
	       clustering based on GO annotations, interactive Syntenty
	       plots to study the gene organization of homologous genes
	       and the reliable identification of orthologous genes
	       (through the integration of a complementary set of data
	       types). During this presentation I will elaborate on
	       different methodologies to identify orthologous genes in
	       different species, discuss pitfalls inherent to simple
	       ad-hoc approaches to identify 'functional homologs' and
	       demonstrate how PLAZA 2.0 can facilitate the transfer of
	       functional information between plants. PLAZA 2.0 is
	       available at http://bioinformatics.psb.ugent.be/plaza/.

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