[Seminars] PSB event reminder

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Calendar Name: seminars
Scheduled for: Thursday, September 26 2013, 11:00 - 12:30
Event text:    Dr Jenny Russinova
	       
	       VIB, Dept. of Plant Systems Biology
	       Ghent University
	       
	       Gent
	       BELGIUM
Details:       “Integration and specificity in brassinosteroid
	       signaling” 
	       
	       ABSTRACT
	       Perception of different signals and their integration
	       into appropriate responses is an essential element of
	       the living plant cell, requiring robust yet adaptable
	       biochemical networks. These networks are largely
	       composed of proteins that can interact, move to specific
	       cellular locations, be modified or degraded. The
	       integration of these events often leads to activation or
	       inactivation of downstream transcription factors, which
	       then induce or repress genes. The main interest of the
	       group is to use the brassinosteroid signaling as a model
	       system and to address the question how specificity and
	       integration is achieved at the cellular level. Our
	       resent research revealed that brassinosteroid signaling
	       pathway shares signaling components with the signaling
	       pathway controlling stomatal development in the leaf and
	       hypocotyl epidermis (Gudesblat et al., 2012, Nature Cell
	       Biol.). Conversely, incorporation of shared signaling
	       components into distinct protein complexes through
	       scaffolding molecules and localization of the pathways
	       to different cellular compartments can also ensure
	       crosstalk. Endomembrane trafficking is an integral part
	       of signal transduction as it attenuates signaling and
	       provides spatial and temporal dimensions to signaling
	       events. BRASSINOSTEROID INSENSITIVE1 perceives its
	       ligand, the brassinosteroid hormone at the cell surface
	       and is constitutively endocytosed. We recently uncover
	       the importance of endocytosis for brassinosteroid
	       signaling. A bioactive, fluorescent brassinosteroid was
	       developed and used to visualize endocytosis of
	       brassinosteroid receptor-ligand complexes in living
	       cells. Clathrin- , AP-2- and ARF GEF-dependent endocytic
	       regulation of brassinosteroid signaling from the plasma
	       membrane was postulated (Irani et al., 2012 Nature Chem.
	       Biol.; Di Rubbo et al., 2013 Pant Cell).

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