[Seminars] You are invited to attend “Cross-kingdom RNA trafficking between plants and fungal pathogens and innovative eco-friendly disease control solutions” ON November 16, 2023

[Delphine Verspeel]

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'' Cross-kingdom RNA trafficking between plants and fungal pathogens and innovative eco-friendly disease control solutions '' 



Prof Hailing Jin 




Department of Microbiology and Plant Pathology 
Center for Plant Cell Biology 
Institute for Integrative Genome Biology 
University of California 
Riverside 
USA 








Thursday, November 16, 2023 
11:00 














Small RNAs (sRNAs) are short non-coding RNAs that mediate gene silencing in a sequence-specific manner. We discovered that some sRNAs from eukaryotic pathogens, such as Botrytis cinerea, can be transported into host plant cells and suppress host immunity genes for successful infection (Weiberg et al., Science 2013). We further demonstrated that plants can also send sRNAs into pathogens, mainly using extracellular vesicles, mostly exosomes, to silence fungal virulence genes as part of its immune responses (Cai et al., Science 2018). We identified a group of RNA binding proteins that contribute to the selective sRNA loading into extracellular vesicles (He et al., Nature Plants, 2021). Furthermore, we recently demonstrate that B. cinerea also utilizes extracellular vesicles to secrete sRNAs, which are then enter plant cells through clathrin-mediated endocytosis (He et al., Nature Communications, 2023). Thus, extracellular vesicles play an important role in cross-kingdom RNA trafficking between plants and fungal pathogens. 
In addition, we discovered that environmental RNAi is present in many fungal pathogens, which can take up RNAs from the environment efficiently (Wang et al,, Nature Plants, 2016; Qiao et al., Plant Biotechnology Journal 2021). Applying small RNAs or double-stranded RNAs that target fungal virulence-related genes on plants can effectively inhibit fungal diseases. Innovative pathogen gene-targeting RNA-based antifungal solutions using nanotechnologies represent a new generation of fungicides that are durable and eco-friendly (Qiao et al., Plant Biotechnology Journal, 2023; Niño-Sánchez et al., Journal of Integrative Plant Biology 2023). 






Jozef Schell seminar room 
Technologiepark 71 - 9052 






Invited by Prof Dirk Inzé and Prof Jenny Russinova 

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Genome editing, cutting-edge technology for a sustainable agriculture 

VIB-UGent Center for Plant Systems Biology Ghent University 
Technologiepark-Zwijnaarde 71 
9052 Ghent-Belgium 
Phone: +32(0)9 331 38 00 
[ http://www.psb.vib-ugent.be/ | https://www.psb.ugent.be/ ] 


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