[BBC] Postdoc positions in Comparative Genomics

[Marc van Driel]

Postdoc positions in Comparative Genomics

 

The CMBI at the Nijmegen Center for Molecular Life Sciences has two open
positions for talented and motivated scientists to do bioinformatics
research into:

 

1)      Unraveling patterns behind mental retardation:

We have compiled a catalogue of more than 400 genes, mutations in which
give rise to mental retardation. Several of these genes have already
been demonstrated to act together in molecular pathways. However, the
global biological coherence behind mental retardation genes is unknown.
The challenge is to address this, e.g. via analyzing protein-protein
interactions, via expression in specific tissues, via shared phenotypes
in human and model organisms and via their shared evolutionary origin.
You will query various types of genomics data, including proprietary
gene-expression and functional data in Drosophila, to uncover shared
pathways. Your work will shed light onto genetic design principles that
underlie human brain function and will identify new candidate genes for
mental retardation. 

 

2)      Evolutionary deconstruction of the Ciliome: 

The cilium is a eukaryotic organelle whose malfunction has been shown to
be responsible for a wide array of genetic diseases. Already the
evolutionary analysis of known ciliary proteins and other genomics data
has successfully predicted new ciliary proteins. You will map the origin
and evolution of the ciliome among the eukaryotes to find new candidate
ciliary proteins, to detect sub-modules within the cilium and in general
to link the evolution of the cilium to its functions. 

 

The projects combine the expertise of the Huynen group in the analysis
of genomics data to predict protein function with the expertise in
studying genetic disease of the groups of Annette Schenck and Ronald
Roepman (Human Genetics, Nijmegen Center for Molecular Life Sciences).
This collaboration ensures direct experimental testing of interesting
newly predicted candidate proteins and pathways. 

 

The positions are initially for two years with ample possibilities for
extension. Requirements: You have PhD in Bioinformatics or in Natural
Sciences with a published affinity for large-scale Bioinformatics
analyses coupled to in depth study of biological systems. Salary:
starting at 40.458 - 46.695 Euro, depending on experience. 

 

For more information please contact Martijn Huynen (huynen at cmbi.ru.nl
<mailto:huynen at cmbi.ru.nl> , www.cmbi.ru.nl). To apply, please e-mail a
letter describing research interests and past research activities, a CV,
and the names of three referees before October 15th , 2009.

 

 

 

 

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