[BBC] PhD / Postdoc position on Evolutionary Cell Biology of the Mitotic Checkpoint

[berend snel]

*PhD / Postdoc position on Evolutionary Cell Biology of the Mitotic 
Checkpoint.*

We are looking for a motivated PhD student or postdoc with experience in 
evolutionary bioinformatics, and with affinity for understanding the 
role of protein networks in biological processes. The project seeks to 
derive functional insights into chromosome segregation from the study of 
protein co-evolution at the residue, motif, domain and protein level 
within the mitotic checkpoint signaling pathway. Novel and improved 
co-evolution studies are now possible thanks to an avalanche of new 
complete genomes. The project will encompass development of new tools 
and continuous refinement of a pipeline to describe and detect 
co-evolution between proteins. Importantly this bioinformatic pipeline 
will be used for generating detailed predictions on function and 
evolution of mitotic checkpoint proteins. As such, the candidate is 
expected to develop extensive expertise on chromosome segregation in 
general, and the mitotic checkpoint in particular, to push the limits on 
these predictions.

*Department information*

The lab of Geert Kops is part of the department of Medical Oncology and 
the department of Molecular Cancer Research at the UMC Utrecht. These 
departments are renowned for their fundamental and translational cancer 
research. The lab is located in the Stratenum building, that 
additionally houses various state-of-the-art facilities, including 
microscopy, proteomics, cell-screening, biochemistry and next-generation 
sequencing. The Kops lab consist of 6 PhD student, 3 postdocs and 4 
technicians.

The lab of Berend Snel is part of the Institute for Biodynamics and 
Biocomplexity of the Faculty of Science. This institute aims to achieve 
a systems-level understanding of complex dynamic processes and their 
evolution through close interaction between experimentation and 
computational biology. The Snel group currently consists of 4 PhD 
students and 1 postdoc working on the evolution and function of 
different biological systems.

*How to apply*

Please send your CV, along with a cover letter outlining your specific 
qualifications for the preferred positions including contact information 
for at least two references to Dr. Berend Snel, B.Snel at uu.nl.


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