[BBC] PhD Candidate - Single Cell Transcriptomics of the Early Stages of Alzheimer’s Disease

[Mark Fiers]

Dear all,

We are looking for a PhD candidate to explore single-cell transcriptome
data of the early stages of Alzheimer's Disease.

The early stages of Alzheimer's disease are still poorly understood. It is
unknown how the different cell types react to early amyloid stress and how
these changes propagate through the different brain regions (in particular
the hippocampus). In this project we will apply single cell transcriptomics
to an Alzheimer's mouse model. Combining this data with a number of
different technologies, such as in-situ hybridization and
electrophysiology, will allow us to build a detailed spatio-temporal model,
distinguishing different cell types, of the earliest steps in the
progression of Alzheimer's disease.

The candidate will work on the analysis of transcriptomics data and
integrate this data with data from other sources, both locally generated,
as well as public data. The ultimate goal is to generate a spatial and
temporal model of the transcriptional changes at the onset of AD.

More information:
http://www.vib.be/en/jobs/Pages/PhD-Candidate---Single-Cell-Transcriptomics-of-the-Early-Stages-of-Alzheimer%E2%80%99s-Disease.aspx

With best regards
Mark Fiers
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