[BBC] Postdoc TU Delft: modelling single-cell heterogeneity in response to proton therapy

[Joana Gonçalves -EWI]

Dear all,

We are looking for a 2-year computational postdoc in a flagship collaboration between the TU Delft, the Erasmus MC, and the Holland Proton Therapy Center under the Convergence for Health and Technology initiative.

The project aims to model single-cell heterogeneity in response to proton therapy in head and neck cancer patient biopsies. The computational postdoc at the TU Delft will work alongside a fellow experimental postdoc at Erasmus MC to: (1) characterize (un)treated tumor samples at the single-cell level using optogenetic imaging, photoselection, and single-cell RNA sequencing; (2) model single-cell and subclonal response to treatment based on transcriptomic profiles and functional imaging features, including cell dynamics and morphology; (3) identify and interpret biomarker signatures associated with resistance to proton therapy.

The successful candidate should have a background in computer science or related, and experience in bioinformatics.

There is ample opportunity for innovation and development of new ideas on fundamental algorithmic and statistical learning topics, in connection with this and other projects ongoing in the lab. The postdoc will be primarily affiliated with the Gonçalves lab in the Department of Intelligent Systems at the TU Delft, with a secondary appointment in the Chien lab at Erasmus MC, and will be embedded in a larger network of 24 postdocs funded by the Convergence initiative. The successful candidate will work in a highly multidisciplinary environment, and interact with a diverse group of faculty in computer science, pattern recognition and machine learning, bioinformatics, biomedical science, and molecular biology. This project will also enable access to and collaboration with other leading research scientists and laboratories in the Netherlands, including the Oncode Institute.

See some of what we are currently working on at http://joanagoncalves.org/people.html.

If you believe that you are a great fit, we would like to hear from you!
For more information please contact me (joana.goncalves at tudelft.nl<mailto:joana.goncalves at tudelft.nl>), or apply directly at https://convergence.healthandtechnology.nl/square/position/37.
Applications sent before July 18, 2020 will be given priority.

Please, share this information with potential candidates.

Kind regards,
Joana

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Joana Gonçalves
Assistant Professor

TU Delft
Faculty EEMCS, Dept. Intelligent Systems
Van Mourik Broekmanweg 6, 2628 XE Delft
Building 28, Office E05.060
http://joanagoncalves.org
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