[Seminars] PSB event reminder

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Calendar Name: seminars
Scheduled for: Wednesday, December 16 2009, 15:00 - 16:30
Event text:    Dr M. Madan Babu
	       
	       MRC Laboratory of Molecular Biology
	       University of Cambridge
	       UK
Details:       ABSTRACT
	       Altered abundance of several intrinsically unstructured
	       proteins (IUPs) has been associated with perturbed
	       cellular signaling that may lead to pathological
	       conditions such as cancer. Therefore, it is important to
	       understand how cells precisely regulate the availability
	       of IUPs. We observed that regulation of transcript
	       clearance, proteolytic degradation, and translational
	       rate contribute to controlling the abundance of IUPs,
	       some of which are present in low amounts and for short
	       periods of time. Abundant phosphorylation and low
	       stochasticity in transcription and translation indicate
	       that the availability of IUPs can be finely tuned.
	       Fidelity in signaling may require that most IUPs be
	       available in appropriate amounts and not present longer
	       than needed.

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