[Seminars] PSB event reminder
contact at psb.vib-ugent.be
contact at psb.vib-ugent.be
Wed Dec 16 13:10:02 CET 2009
Calendar Name: seminars
Scheduled for: Wednesday, December 16 2009, 15:00 - 16:30
Event text: Dr M. Madan Babu
MRC Laboratory of Molecular Biology
University of Cambridge
UK
Details: ABSTRACT
Altered abundance of several intrinsically unstructured
proteins (IUPs) has been associated with perturbed
cellular signaling that may lead to pathological
conditions such as cancer. Therefore, it is important to
understand how cells precisely regulate the availability
of IUPs. We observed that regulation of transcript
clearance, proteolytic degradation, and translational
rate contribute to controlling the abundance of IUPs,
some of which are present in low amounts and for short
periods of time. Abundant phosphorylation and low
stochasticity in transcription and translation indicate
that the availability of IUPs can be finely tuned.
Fidelity in signaling may require that most IUPs be
available in appropriate amounts and not present longer
than needed.
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