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Calendar Name: seminars
Scheduled for: Tuesday, September 21 2010, 15:00 - 16:30
Event text:    Toshihiro Obata
	       
	       Max-Planck-Institute für Molecular Plant Physiology
	       
	       Potsdam-Golm
	       GERMANY
Details:       "Metabolic response to oxidative stress in Arabidopsis"
	       
	       ABSTRACT
	       Plants must reconfigure their metabolic network under
	       stress conditions to prevent the accumulation of
	       reactive oxygen species (ROS) and to produce
	       indispensable metabolites. We have investigated the
	       response of Arabidopsis roots to menadione-induced
	       oxidative stress by means of metabolite profiling and
	       transcriptome analysis. The results suggested the
	       importance of mitochondrial metabolism in stress
	       response and also highlighted a complex relationship
	       between the levels of transcripts, metabolites, and
	       metabolic flux. We hypothesise the reassembly of enzyme
	       protein complexes as a molecular mechanism of
	       mitochondrial metabolic regulation. A proteomic approach
	       using blue-native/SDS-PAGE revealed that some
	       mitochondrial enzymes associated to or dissociated from
	       a protein complex under oxidative stress. These results
	       suggest the regulation of the TCA cycle, glycolysis,
	       ascorbate and amino acid metabolism under oxidative
	       stress by reassembly of enzyme supercomplexes.

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