[Seminars] PSB event reminder
contact at psb.vib-ugent.be
contact at psb.vib-ugent.be
Mon Nov 28 09:10:01 CET 2011
Calendar Name: seminars
Scheduled for: Monday, November 28 2011, 11:00 - 12:30
Event text: Prof Natasha Raikhel
Center for Plant Cell Biology &
the Institute for Integrative Genome Biology
Department of Botany and Plant Sciences
University of California
Riverside
USA
Details: Chemical Biology:Towards a Systems View of the
Endomembrane system
ABSTRACT
Although it is known that proteins are delivered to and
recycled from the plasma membrane (PM) via endosomes,
the nature of the compartments and pathways responsible
for cargo and vesicle sorting and cellular signaling is
poorly understood. Such highly dynamic processes are not
easily approached genetically. To define and dissect
specific recycling pathways, rapid-acting chemical
affecters of proteins involved in vesicle trafficking,
especially through endosomes, would be invaluable. Thus,
we identified chemicals affecting essential steps in
PM/endosome trafficking by utilizing the intensely
localized PM transport at the tips of germinating
tobacco pollen tubes. We screened diverse chemical
libraries for those that interfered with pollen
germination and tip growth. We found that many also had
effects in Arabidopsis roots for which there are several
well-characterized marker proteins that cycle to and
from the plasma membrane. Recent results from our
screens will be discussed.
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