[Seminars] PSB event reminder
contact at psb.vib-ugent.be
contact at psb.vib-ugent.be
Tue Nov 27 13:50:01 CET 2012
Calendar Name: seminars
Scheduled for: Thursday, November 29 2012, 11:00 - 12:30
Event text: Prof Kathleen Marchal
VIB, Dept. of Plant Systems Biology
Ghent University
Gent
Dept. of Microbial and Molecular Systems K.U.Leuven
Leuven
BELGIUM
Details: Systems Biology: Network-based data integration
ABSTRACT
In current wet-lab practice high-throughput expression
profiling techniques are used to find components of
response pathways, e.g. mRNA profiling focuses on
identifying genes that are differentially expressed
following stimuli or ChIP-chip techniques are being used
to identify TF-target interactions. With the
availability of next-gen sequencing, complete genotyping
in combination with expression analysis allows finding
genetic loci underlying interesting phenotypic traits.
Each of the experiments mentioned above eventually
results in a list of candidate genes or loci that all
relate to the same phenotype of interest. Computational
analysis of such unstructured lists will in most cases
be restricted to a simple functional enrichment analysis
to elucidate the potential pathways or functions the
candidate genes belong to or to identify functionally
related gene sets, but the interactions between the
identified candidate genes or their role in the global
molecular network of the cell remains unknown. To get a
more structured insight in these results, we focus our
research on developing tools that allow analyzing
dedicated in-house experimental expression data and
interrogating them with publicly available omics data.
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