[Seminars] PSB event reminder

[contact at psb.vib-ugent.be]

Calendar Name: seminars
Scheduled for: Thursday, November 29 2012, 11:00 - 12:30
Event text:    Prof Kathleen Marchal
	       
	       VIB, Dept. of Plant Systems Biology
	       Ghent University
	       
	       Gent
	       
	       Dept. of Microbial and Molecular Systems K.U.Leuven
	       
	       Leuven
	       BELGIUM
Details:       “Systems Biology: Network-based data integration”
	       
	       ABSTRACT
	       In current wet-lab practice high-throughput expression
	       profiling techniques are used to find components of
	       response pathways, e.g. mRNA profiling focuses on
	       identifying genes that are differentially expressed
	       following stimuli or ChIP-chip techniques are being used
	       to identify TF-target interactions. With the
	       availability of next-gen sequencing, complete genotyping
	       in combination with expression analysis allows finding
	       genetic loci underlying interesting phenotypic traits.
	       Each of the experiments mentioned above eventually
	       results in a list of candidate genes or loci that all
	       relate to the same phenotype of interest. Computational
	       analysis of such unstructured lists will in most cases
	       be restricted to a simple functional enrichment analysis
	       to elucidate the potential pathways or functions the
	       candidate genes belong to or to identify functionally
	       related gene sets, but the interactions between the
	       identified candidate genes or their role in the global
	       molecular network of the cell remains unknown.  To get a
	       more structured insight in these results, we focus our
	       research on developing tools that allow analyzing
	       dedicated in-house experimental expression data and
	       interrogating them with publicly available omics data.

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