[Seminars] Seminar Prof Hiroyuki Osada TOMORROW at 3 pm in the Schell room

[Delphine Verspeel]

Van: "Delphine Verspeel" <delphine.verspeel at psb.vib-ugent.be> 
Aan: "meetings" <meetings at psb.vib-ugent.be> 
Cc: "Lieve Ongena" <Lieve.Ongena at vib.be> 
Verzonden: Donderdag 23 juni 2022 15:29:31 
Onderwerp: You are invited to attend “Regulation of tenuazonic acid production in a plant pathogenic fungus, Pyricularia oryzae” ON July 14, 2022 


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'' Regulation of tenuazonic acid production in a plant pathogenic fungus, Pyricularia oryzae '' 


Prof Hiroyuki Osada 

Department of Pharmaceutical Sciences 
University of Shizuoka 
RIKEN Center for Sustainable Resource Science 
JAPAN 


Thursday, July 14, 2022 
15:00 


















Rice blast disease is the most important disease of rice worldwide because the disease results in total crop failure. The disease is caused by Pyricularia oryzae ( Magnaporthe oryzae ), a pathogenic fungus. P. oryzae has many secondary metabolism genes but the 

most secondary metabolites are scarcely produced or not produced under laboratory conditions. Secondary metabolite production might be strictly regulated to produce under specific environmental conditions, such as upon the infection. 

In my presentation, the induced production of tenuazonic acid, a mycotoxin, in P. oryzae upon the infection will be discussed. 

1) Identification of tenuazonic acid biosynthetic gene cluster in P. oryzae . 

2) Biosynthetic machinery for tenuazonic acid synthesis. 

3) Battle between pathogenic fungus and rice plant. 



References 

1 Yun, C. S., Motoyama, T. & Osada, H. Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nature Commun 6 , 8758 (2015). 

2 Yun, C. S., Motoyama, T. & Osada, H. Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae. ACS Chem Biol 12 , 2270-2274 (2017). 

3 Yun, C. S. et al. Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1. J Biol Chem 295 , 11602-11612 (2020). 

4 Kashiwa, T., Motoyama, T., Yoshida, K., Yun, C. S. & Osada, H. Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae. Biosci Biotechnol Biochem 86 , 135-139 (2021). 

5 Motoyama, T., Yun, C. S. & Osada, H. Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae. J Ind Microbiol Biotechnol 48 , kuab058 (2021). 














Jozef Schell seminar room 
Technologiepark 71 - 9052 




Invited by Prof Dirk Inzé 

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