[BBC] Vacancy: PhD-position in Computational Microbiology

[Thomas Abeel - EWI]

Dear all,


We are looking for a PhD candidate in bioinformatics at the Delft 
Bioinformatics Lab at TU Delft, The Netherlands, to work on a project 
looking to develop rapid diagnosis of drug resistant and mixed TB 
infections.


Project and application details below.


best,
Thomas


*
PhD-position in Computational Microbiology*

*Title
*Rapid diagnosis of drug resistant TB infections//

*Project leader*

Thomas Abeel

Delft Bioinformatics Lab – Pattern Recognition and Bioinformatics – 
Department of Intelligent Systems

Faculty of EEMCS, Delft University of Technology (TU Delft)*

*

*Job description*

Despite treatment options, TB is killing 1.5 million people each year, 
the vast majority in developing nations. Current diagnostics often take 
several weeks or months, which is too long to save the lives of the 
patients or to prevent further transmission. This project collaborates 
with Dr. Pym of the K-RITH research institute in Durban South-Africa to 
develop an innovative rapid diagnostic that accurately identifies 
currently undiagnosable TB infections, i.e. mixed and drug resistant 
infections. This will be done by computationally identifying markers 
that are indicative of these infections in genomic data which are then 
used to design the diagnostic using existing sequencing technology.

Your objectives in this project are to identify novel drug-resistance 
conferring mutations, to create a predictive model for drug resistance 
and mixed infections in TB and to explore the options to turn these 
insights into a prototype point-of-care molecular diagnostic. We have a 
collection of sequencing and meta-data from >8000 diverse TB strains. We 
now have the unique opportunity to leverage these data to make a global 
societal impact. You will integrate public and private data sets to 
associate mutations with phenotypes, such as drug resistance, with 
state-of-the-art computational approaches.

*Requirements*

The ideal candidate has an Msc degree in bioinformatics or alternatively 
a degree in computer science or (micro-)biology with strong affinity or 
experience in the complementary field. He/she must be able to work 
effectively in a multidisciplinary team. The candidate shares our view 
that communication skills are important, as is the ability to interact 
with peers, students and technical staff. //

-Programming, algorithm development and scripting experience are desirable

-Wet-lab experience is a plus

-Experience in microbial genomics is a plus

//

*Information and application*

For more information about this position, please contact Dr. T. Abeel 
(t.abeel at tudelft.nl <mailto:t.abeel at tudelft.nl>). To apply, please 
e-mail a detailed CV (including grades and English certification if 
applicable), cover letter and at least two personal letters of 
recommendation. Please submit your full application by June 1, 2016 to 
t.abeel at tudelft.nl <mailto:t.abeel at tudelft.nl>.More information about 
the section: http://bioinformatics.tudelft.nl/and the project leader: 
http://www.abeel.be/

*Conditions of employment
*TU Delft offers an attractive benefits package, including a flexible 
work week and the option of assembling a customised compensation and 
benefits package. Salary and benefits are in accordance with the 
Collective Labour Agreement for Dutch Universities.
As a PhD candidate you will be enrolled in the TU Delft Graduate School. 
TU Delft Graduate School provides an inspiring research environment; an 
excellent team of supervisors, academic staff and a mentor; and a 
Doctoral Education Programme aimed at developing your transferable, 
discipline-related and research skills. Please visit www.phd.tudelft.nl 
for more information.


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