February 2013 - BBClist - maillist.psb.ugent.be

Computational Cancer Biology Positions
by Lodewyk Wessels 12 Jul '13

12 Jul '13

COMPREHENSIVE COMPUTATIONAL MODELING FOR COMBINATION TREATMENT DESIGN PROJECT OUTLINE All cancers arise due to alterations in their genomes. Although insight into the genetic lesions in tumors by genome sequencing does already assist in selecting some drug regimens, it rarely results in disease eradication due to the emergence of drug-resistance. More sophisticated combination therapies in which several oncogenic pathways are targeted simultaneously could alleviate this problem. However, at present we are unable to extract and interpret the necessary information from tumors to predict which drug regimen will be most adequate. In this project we will collaborate with Welcome Trust Sanger Center and employ the 1000 cancer cell line data set to tackle this problem. This data set comprises large-scale molecular characterization and cancer drug screening of all cell lines for 400 anti-cancer drugs. The molecular data currently consists of gene expression, copy number (SNP-6), and whole exome sequencing data and is being expanded. The successful candidate will work closely with scientists at the Welcome Trust Sanger Center and the Netherlands Cancer Institute and employ computational approaches to mine this rich, valuable pre-clinical resource. Potential results include 1) new molecular biomarkers to identify sensitive populations 2) repositioning of existing drugs in other tumor types and 3) potential drug combinations aimed at overcoming resistance mechanisms. Hypotheses emerging from these analyses will be validated in model systems and where possible in clinical settings. CANDIDATE REQUIREMENTS – EDUCATION AND EXPERIENCE We are seeking highly motivated Postdoc or PhD candidates with a degree in bioinformatics, computer science, mathematics or physics and with a strong cancer biology interest. Preferably applicants should have a documented experience in analyzing high-throughput genomic data. The candidate needs to be proficient in common bioinformatics scripting and programming languages. Fluency in spoken and written English is a strong requirement. LOCATION The project involves groups at the Netherlands Cancer Institute, Amsterdam (Rene Bernards, Molecular Carcinogenesis, and Lodewyk Wessels, Computational Biology) and the Welcome Trust Sanger Institute (Mathew Garnet and Ultan McDermott, Cancer Genome Project). This position will be embedded in the Computational Biology Group lead by Lodewyk Wessels. CONTACT DETAILS Please contact Lodewyk Wessels, tel. +31 20 512 7987 or e-mail: l.wessels(a)nki.nl. When applying, please ensure you include a CV, list of publications and the names and addresses of at least two persons that can be approached as references. Also see bioinformatics.nki.nl for further information. CLOSING DATE 3 February 2013

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NBIC PhD course on Managing Life Science Information: registration is open!
by Celia van Gelder 01 May '13

01 May '13

*NBIC PhD Course on Managing Life Science Information (2nd edition) *Course coordinators: Marco Roos, Scott Marshall _Date:_ 17-21 October 2011 (one week of tutorials) and a final workshop on Friday 28 October 2011 to discuss project results _Location:_ Science Park, Amsterdam _Registration:_ http://www.nbic.nl/education/nbic-phd-school/enrolment/ _Website: _http://www.nbic.nl/education/nbic-phd-school/course-schedule/managing-life-science-information/ Did you ever suspect that the data that you need is somewhere but neither discoverable nor accessible? Have you ever produced valuable data that nobody can use anymore, including yourself? Have you ever wondered how to create a federation of distributed data sources? If you do not want your data to end up in a data graveyard, and for many other information management issues, we have organised a course for you. In this course we will teach you methods to make data shareable and self-describing. You will learn how: 1. the 'Linked Data' principle works and how it can be applied for 'meaningful' data integration 2. to expose your local data (including relational databases) for use in other systems. 3. Web Services can be used to analyse data from anywhere. 4. text mining can be applied to link resources such as biobanks. 5. human knowledge can be made computable and associated with data. 6. to make your data publishable artifacts for which you can get scientific credit. 7. to use tools such as MolGenis <http://www.molgenis.org/>, Taverna <http://www.taverna.org.uk/>, SPARQL <http://www.w3.org/TR/sparql11-query/>, D2RQ <http://www4.wiwiss.fu-berlin.de/bizer/d2rq/>, SWObjects <http://tinyurl.com/swobjects-swat4ls>, NCBO's BioPortal <http://bioportal.bioontology.org/>, Anni <http://www.biosemantics.org/index.php?page=anni-2-0>, LarKC <http://larkc.org/>(Large Knowledge Collider). 8. to collaboratively solve an information management problem _Program_ (tentative) Monday: Introduction by leading Semantic Web expert Prof. Dr. Frank van Harmelen; Hands-on with RDF and SPARQL (Scott Marshall) Tuesday: XML, RDF, Minimal information models, and exposing data from local databases (Scott Marshall); hands-on with MolGenis (Erik Roos) Wednesday: Data integration with Web Services (Katy Wolstencroft); hands-on with Taverna (Katherine Wolstencroft) Thursday: Knowledge management and nano-publication (Andrew Gibson); hands-on federated queries with SWObjects (Scott Marshall) Friday: Text mining for linking biobanks and hands-on with Anni (Marco Roos, Kristina Hettne); Hands-on with LarKC (Spyros Kotoulas); DRINKS!!! -- Dr. Celia W.G. van Gelder Coordinator Education CMBI Projectleader Education NBIC tel. +31-(0)24-3666120 e-mail: C.vanGelder(a)cmbi.ru.nl websites: www.cmbi.ru.nl, www.nbic.nl Postal address: CMBI 260 Radboud University Nijmegen-Medical Centre /NCMLS PO Box 9101, 6500 HB Nijmegen The Netherlands

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Registration open for EBI Roadshow Amsterdam 9-10 April 2013
by Celia van Gelder 12 Mar '13

12 Mar '13

Dear colleague, On 9-10 April 2013, NBIC and AMC will organize an EBI Roadshow at AMC Amsterdam. Topics are _April 9, 2013:_ Introduction to the databases at the EBI Sequence Searching and Alignment _April 10, 2013_ ArrayExpress: Public database for transcriptomics data & Gene Expression Atlas Ensembl for new Ensembl users This course is aimed at researchers across the Netherlands who wish to develop their understanding of the data resources and tools available from EMBL-EBI. The programme provides an overview of commonly-used EBI public resources for the analysis of nucleotide, protein and microarray data. Delegates will learn about these data resources in short lectures and then gain hands-on experience in using them to analyse data. The practical exercises use web-browser-based tools and assume no previous training in bioinformatics programming. Registration is now open. See: http://www.nbic.nl/education/course-overview/pages3/1/coursedetails/ebi-roa… a page including programme and link to registration form. Furthermore, you can find a flyer in the attachment. I want to ask you if you can spread this information in your organisation. Thank you, Best regards, Celia van Gelder NBIC Education Dr. Celia W.G. van Gelder Coordinator Education CMBI Projectleader Education NBIC tel. +31-(0)24-3666120 e-mail:C.vanGelder@cmbi.ru.nl websites:www.cmbi.ru.nl,www.nbic.nl Postal address: CMBI 260 Radboud University Nijmegen-Medical Centre /NCMLS PO Box 9101, 6500 HB Nijmegen The Netherlands

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Senior Project Manager
by Johann Pellet 28 Feb '13

28 Feb '13

Senior Project Manager based at CNRS-EISBM in Lyon in relation with the IMI eTRIKS Consortium on Information and Knowledge Management Services We are seeking an experienced individual to contribute to the management of community engagement and outreach activities in the newly formed eTRIKS Consortium, funded by the Innovative Medicines Initiative (IMI) of the European Commission 7th Framework Programme and the European Federation of Pharmaceutical Industries and Associations. Scientific Project: The eTRIKS Consortium is dedicated to delivering European Translational Information and Knowledge Management Services initially for all IMI projects, then for other European translational research projects. These projects encompass translational bioinformatics, clinical research informatics, health/clinical informatics and the development of new analytical tools. They use tranSMART as part of the software knowledge management platform: http://www.etriks.org; http://www.transmartproject.org Job context: She/he will be working closely with the academic and pharmaceutical partners of eTRIKS, interfacing with the community of users in IMI, FP7 and Horizon 2020. The selected candidate will be based in Lyon-Gerland within the CNRS-EISBM team led by Charles Auffray, hosted by Claude Bernard University and the Lyonbiopole competitive cluster on the Charles Mérieux campus:http://www.eisbm.org; http://workshop.eisbm.org Job description: The ideal candidate should be able to proactively lead the development of the community of users of the eTRIKS platform, engaging multiple academic and industrial partners in a pre-competitive collaborative innovation effort. The objective is to reach international harmonization of the use of analytical and modeling methods in the context of the fast evolving area of translational research and systems medicine. In particular the candidate is expected : • to establish and maintain interactions with IMI & non-IMI translational projects regarding their knowledge management and informatics needs; • to coordinate the activities of eTRIKS with the open source development community around the eTRIKS platform; • to coordinate the provision of education to IMI and non-IMI translational scientists, patient advocacy groups, commercial service providers regarding the mission and services of the eTRIKS consortium. Required Experience/Skills: • PhD or MBA/Engineering degree in biomedical/computational research • Significant experience in academic or industrial project management • Experience in Open Innovation and Agile project management • Familiarity with a UNIX/Linux HPC environment with relational databases • Knowledge of data analysis workflows and supporting software • Rigour, autonomy and excellent relational and teamwork skills • Proven distributed project management and communication skills in English Contract Duration: Available immediately for two years with possible one-year extension. Salary: Depending on qualifications and experience, based on CNRS salary grid. Application: Send CV, cover letter and names of two references to Charles Auffray Email: jobs(a)eisbm.org More information at: http://job.eisbm.org/senior-project-manager-etriks/ References: - Auffray C, Chen Z, Hood L. (2009) Systems medicine: the future of medical genomics and heathcare. Genome Med. 1:29. - Szalma S, Koka V, Khasanova T, Perakslis, ED. (2010) Effective knowledge management in translational medicine. Translational Med 8:68. - Szalma S, Koka V, Khasanova T, Perakslis ED. (2010) How informatics can potentiate precompetitive open-source collaboration to jump-start drug discovery and development. Clin Pharmacol Therapeutics 87:614-616. - Hood L, Balling R, Auffray C. (2012) Revolutionizing medicine in the 21st century through systems approaches. Biotechnol. J. 7:992-1001.

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Senior Researcher Position
by Johann Pellet 28 Feb '13

28 Feb '13

Senior Researcher Position in Bioinformatics and Systems Biology based at CNRS-EISBM in Lyon in relation with the IMI eTRIKS Consortium on Information and Knowledge Management Services We are seeking an experienced individual to lead the Biomedical Personal Data Protection & Ethics activities of the newly formed eTRIKS Consortium, funded by the Innovative Medicines Initiative (IMI) of the European Commission 7th Framework Programme and the European Federation of Pharmaceutical Industries and Associations. Scientific Project: The eTRIKS Consortium is dedicated to delivering European Translational Information and Knowledge Management Services initially for all IMI projects, then for other European translational research projects. These projects encompass translational bioinformatics, clinical research informatics, health/clinical informatics and the development of new analytical tools. They use tranSMART as part of the software knowledge management platform: http://www.etriks.org; http://www.transmartproject.org Job context: She/he will be working closely with academic partners at Imperial College in London and the Luxembourg Center for Systems Biomedicine, and the academic and pharmaceutical partners of eTRIKS. The selected candidate will be based in Lyon-Gerland within the CNRS-EISBM team led by Charles Auffray, hosted by Claude Bernard University and the Lyonbiopole competitive cluster on the Charles Mérieux campus: http://www.eisbm.org; http://workshop.eisbm.org Job description: The ideal candidate should be able to proactively lead the development and implementation of complex workstreams based on data analysis and modeling methods, and engage multiple academic and industrial partners in a pre-competitive collaborative innovation effort, based on the specific needs of eTRIKS project partners. The objective is to reach international harmonization of the use of analytical and modeling methods in the context of the fast evolving area of translational research and systems medicine. In particular the candidate is expected : • to contribute to enhancement of the underlying tranSMART system with required analytical functions for analysis and integration of clinical and omics data; • to develop advanced analytical methods and workflows (e.g. power calculation in clinical study design), and novel approaches for disease and target specific knowledge enrichment (e.g. pathways/disease network models); • to outreach to network disease modelling communities (e.g. Sage Bionetworks, openBEL, Garuda); • to provide scientific support for eTRIKS users on the use of analytics features of the system through training materials and reusable workflows. Required Experience/Skills: Candidates should have a proven track record of research, management and implementation of the ethical and legal (i.e. personal data protection) frameworks of biomedical research and their interaction with information and communication technology. The required proven skills and experience include: • PhD or MS/Engineering degree in biomedical and/or computational research • Significant experience in academic or industrial biomedical research • Statistical programming languages such as R, Matlab, Perl, Python, C • Working in a UNIX/Linux HPC environment with relational databases • Omics data analysis using ontologies and controlled vocabularies • Experience in integration of heterogeneous high-dimensional data types • Knowledge in network inference, analysis and modeling • Development of data analysis workflows and supporting software • Rigour, autonomy and excellent relational and teamwork skills • Proven distributed project management and communication skills in English Contract Duration: Available immediately for two years with possible one-year extension. Salary: Depending on qualifications and experience, based on CNRS salary grid. Application: Send CV, cover letter and names of two references to Charles Auffray Email: jobs(a)eisbm.org More information at: http://job.eisbm.org/senior-research-position-etriks/ References: - Auffray C, Chen Z, Hood L. (2009) Systems medicine: the future of medical genomics and heathcare. Genome Med. 1:29. - Szalma S, Koka V, Khasanova T, Perakslis, ED. (2010) Effective knowledge management in translational medicine. Translational Med 8:68. - Szalma S, Koka V, Khasanova T, Perakslis ED. (2010) How informatics can potentiate precompetitive open-source collaboration to jump-start drug discovery and development. Clin Pharmacol Therapeutics 87:614-616. - Hood L, Balling R, Auffray C. (2012) Revolutionizing medicine in the 21st century through systems approaches. Biotechnol. J. 7:992-1001.

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Personal Data Protection Manager in Lyon
by Johann Pellet 27 Feb '13

27 Feb '13

Personal Data Protection Manager based at CNRS-EISBM in Lyon in relation with the IMI eTRIKS Consortium on Information and Knowledge Management Services We are seeking an experienced individual to lead the Biomedical Personal Data Protection & Ethics activities of the newly formed eTRIKS Consortium, funded by the Innovative Medicines Initiative (IMI) of the European Commission 7th Framework Programme and the European Federation of Pharmaceutical Industries and Associations: http://www.imi.europa.eu/. Scientific Project: The eTRIKS Consortium is dedicated to delivering European Translational Information and Knowledge Management Services initially for all IMI projects, then for other European translational research projects. These projects encompass translational bioinformatics, clinical research informatics, health/clinical informatics and the development of new analytical tools. They use tranSMART as part of the software knowledge management platform: http://www.etriks.org; http://www.transmartproject.org Job context: She/he will be working closely with academic partners at Imperial College in London and the Luxembourg Center for Systems Biomedicine, with Sanofi and the 9 other pharmaceutical partners of eTRIKS. The selected candidate will be based in Lyon-Gerland within the CNRS-EISBM team led by Charles Auffray, hosted by Claude Bernard University and the Lyonbiopole competitive cluster on the Charles Mérieux campus: http://www.eisbm.org; http://workshop.eisbm.org Job description: The ideal candidate should be able to proactively lead complex workstreams on data security and privacy monitoring and compliance, and engage multiple academic and industrial partners in a pre-competitive collaborative innovation effort. The objective is to reach international harmonization of personal data protection rules in the context of the fast evolving area of translational research and systems medicine. Required Experience/Skills: Candidates should have a proven track record of research, management and implementation of the ethical and legal (i.e. personal data protection) frameworks of biomedical research and their interaction with information and communication technology. The required proven skills and experience include: • Previous significant experience in data protection and/or ethics in Europe • Experience in biomedical and clinical research in academy and/or industry • Proven distributed project management and communication skills in English • Experience in information security (technical knowledge would be a plus) Contract Duration: Available immediately for two years with possible one-year extension. Salary: Depending on qualifications and experience, based on CNRS salary grid. Application: Send CV, cover letter and names of two references to Charles Auffray Email: jobs(a)eisbm.org References: - Szalma S, Koka V, Khasanova T, Perakslis, ED. (2010) Effective knowledge management in translational medicine. Translational Med 8:68. - Szalma S, Koka V, Khasanova T, Perakslis ED. (2010) How informatics can potentiate precompetitive open-source collaboration to jump-start drug discovery and development. Clin Pharmacol Therapeutics 87:614-616. More information at: http://job.eisbm.org/personal-data-protection-manager-etriks/

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Two Junior Post-doctoral Positions in Bioinformatics and Systems Biology in Lyon
by Johann Pellet 27 Feb '13

27 Feb '13

Two Junior Post-doctoral Positions in Bioinformatics and Systems Biology at CNRS-EISBM in Lyon in relation with the IMI U-BIOPRED Consortium on Severe Asthma We are looking for several dynamic and self-driven candidates thrilled to join an international cross-disciplinary team of biologists, clinicians and computer scientists from academy and industry in their efforts to overcome the hurdles in understanding and treating severe asthma. Scientific Project: The U-BIOPRED Consortium (Unbiased BIOmarkers for PREDiction of respiratory disease outcomes) aims at understanding severe asthma phenotypes through an integrative systems biology approach. It involves scientists from universities, research institutes, hospitals, the pharmaceutical industry and small companies across Europe. It is funded by the Innovative Medicines Initiative (IMI) of the European Commission 7th Framework Programme and the European Federation of Pharmaceutical Industries and Associations: http://www.imi.europa.eu/; http://www.ubiopred.european-lung-foundation.org Job context: She/he will be based in Lyon-Gerland within the CNRS-EISBM team led by Charles Auffray, hosted by Claude Bernard University and the Lyonbiopole competitive cluster on the Charles Mérieux campus: http://www.eisbm.org; http://workshop.eisbm.eu The successful candidates will participate in the computational analysis of clinical and high-diemensional data (genetic, transcriptomic, proteomic, lipidomic, breathomic) produced by all U-BIOPRED academic and industrial partners and companion projects to identify biomarker fingerprints, and integrate them into severe asthma phenotype handprints of clinical utility. Job description: The ideal candidates hold a PhD degree specializing in analysis, integration, clustering and modelling of complex, heterogeneous biological datasets. He/she will collaborate closely with a multi-disciplinary team of computer scientists, bioinformaticians, biologists and medical doctors. Excellent communication, management and reporting skills in English are essential for this role, which entails travelling across Europe for joint working sessions at partners sites. Required Experience/Skills: - PhD degree in biomedical and/or computational research - Knowledge in statistical analyses and clustering of omics data - Experience in integration of heterogeneous high-dimensional data types - Knowledge in network inference, analysis and modelling - Experience with graphical models such as Bayesian networks - Rigour, autonomy and excellent relational and teamwork skills Contract Duration: Available immediately for one year with a possible extension. Salary: Depending on qualifications and experience, based on CNRS salary grid. Application: Send CV, cover letter and two references to Charles Auffray Email: jobs(a)eisbm.org References: - Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk P. (2010) An integrative systems biology approach to understanding pulmonary diseases. - Wheelock CE, Goss VM, Balgoma D, Nicholas B, Brandsma J, Skipp PJ, Snowden S, D’Amico A, Horvath I, Chaiboonchoe A, Ahmed H, Ballereau S, Rossios C, Chung KF, Montuschi P, Fowler SJ, Adcock IM, Postle AD, Dahlen SE, Rowe A, Sterk PJ, Auffray C, Djukanovic R, the U-BIOPRED Study Group. (2013) Application of ‘omics technologies to biomarker discovery in inflammatory lung diseases. Eur Respir J. Feb 8.

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Position for a bioinformatician (post-doc) in Guadeloupe, France
by fred opperdoes 27 Feb '13

27 Feb '13

Research Project: Complete Genome Analysis of Naegleria fowleri and Naegleria lovaniensis Background Naegleria is a free-living amoeboflagellate found in freshwater feeding on bacteria. One species, N. fowleri, causes primary amoebic meningoencephalitis (PAM) in man, a rare but rapidly fatal central nervous system disease occurring after exposure to contaminated water. The pathogenic N. fowleri is frequently encountered in thermal waters together with its closest relative, the nonpathogenic N. lovaniensis. Sequences of the internal transcribed spacers (ITS) and the 5.8S ribosomal gene allows to distinguish eight types of N. fowleri, which have an uneven distribution in the world. Objectives : By comparing the genome of N. lovaniensis and that of N. fowleri, identify the genes responsible for the pathogenicity and confirm its probable descent from N. lovaniensis. By comparing the genome of the three most common N. fowleri types (2, 3 and 5) found in PAM cases, confirm the pathogenicity genes and identify suitable markers for phylogenetic analyses of N. fowleri strains. Methods : The complete genome sequence of three strains of N. fowleri belonging to 3 different types and one strain of N. lovaniensis will be determined using an illumina technology, before the arrival of the bioinformatician. The bioinformatician will reconstitute the complete genome of the 4 strains. To assemble the sequences he/she will be able to rely on the complete genome sequence of Naegleria gruberi (41 Mb) available at GenBank. He/she will work at the Pasteur Institute of Guadeloupe in a scientific environment of young scientists investigating the molecular epidemiology of Mycobacterium tuberculosis. He/she will have access to the computers of the Pasteur Institute in Paris through internet. Terms: The project will last for two years. The salary will depend on the finances from a grant for a post doctoral fellowship from the Guadeloupe region. This outcome of the grant will be known around September 2013. If the grant is accepted, the postdoctoral fellowship could begin at the end of 2013. The gross salary will be around 32,000 euros. For further information and for applications contact: Dr. Antoine Talarmin Directeur Institut Pasteur de Guadeloupe Morne Jolivière BP484 97183 Abymes Cedex Guadeloupe France ATALARMIN(a)pasteur-guadeloupe.fr tel : 05 90 89 69 40

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NBIC2013 - reminder abstract submission - deadline March 4
by Femke Francissen 27 Feb '13

27 Feb '13

** NBIC2013 - reminder abstract submission ** NBIC2013 Date: 16 & 17 April 2013 Venue: De Werelt Conference Centre, Lunteren, the Netherlands Website: http://www.aanmelder.nl/nbic2013/ Abstract submission - deadline March 4 Only 5 days left to submit your abstract for an oral presentation at the NBIC2013 or one of her satellite meetings: * NBIC2013 programme: any bioinformatics related subject * Data & Technology session: data management, -stewardship and -interoperability * NSBM Spring Meeting 2013: protein structure and structural bioinformatics (April 16) * Metagenomics Satellite Track: metagenomics and computational analysis of microbial ecosystems (April 17) You can also submit an abstract for a poster presentation or demo! Submit your abstract now: http://www.aanmelder.nl/nbic2013/wiki/Abstract%20submission About NBIC 2013 is the 8th edition of the annual conference organized by the Netherlands Bioinformatics Centre (NBIC)<http://www.nbic.nl/>. NBIC2013 discusses the latest developments in bioinformatics and interrelated disciplines, and their wide-ranging applications in life sciences & health, agriculture, food & nutrition and industrial biotechnology. NBIC2013 offers a cross-disciplinary scientific program of (poster) presentations, application demonstrations and workshops, as well as other opportunities to exchange innovative ideas. More about the conference programme: http://www.aanmelder.nl/nbic2013/ Register here: http://www.aanmelder.nl/nbic2013/subscribe?survey_id=53415 Use #NBIC2013 to Tweet about the conference!

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Junior PI meeting: a satellite of ISMB-ECCB 2013
by Magali Michaut 26 Feb '13

26 Feb '13

Transitioning from Post-doc to (junior) PI is a major step in the scientific career ladder bringing new challenges to the scientist. Key among these challenges is moving from a single project-based responsibility to being responsible for the projects of students, technicians, and postdocs. On top of this, the researcher is expected to be a successful grant writer, a human resources manager, an engaging speaker, etc. In this meeting we aim to bring together scientists who have recently started or wish to start their own research group. This meeting will serve as a platform for building a community of junior PIs within the broader field of Computational Biology. To participate you have to submit a short summary of your scientific research interests and future plans which will be distributed before the event to all participants to facilitate the interactions. They will also be peer-reviewed as part of the participant selection process. One of the most important goals of this meeting is to stimulate peer-to-peer interactions, which requires time and effort. We will thus require all participants to commit to the entire program duration. The total number of delegates will be capped at 50, so don't wait to submit your abstract! ** Submission deadline: April 19 ** https://www.easychair.org/conferences/?jpi2013 Date of the meeting: 20 July 2013 http://www.iscb.org/ismbeccb2013-program/ismbeccb2013-jpi/about-jpi Organizers: Jeroen de Ridder, Delft University of Technology, The Netherlands Venkata P. Satagopam, University of Luxembourg, Luxembourg Manuel Corpas, The Genome Analysis Centre, UK Magali Michaut, Netherlands Cancer Institute, The Netherlands Yana Bromberg, Rutgers University, USA Nils Gehlenborg, Harvard Medical School, USA Geoff Macintyre, University of Melbourne, Australia

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