May 2014 - BBClist - maillist.psb.ugent.be

International Chemical Discovery & Design Course, 16-27 June 2014
by Barbara.vanKampen＠radboudumc.nl 08 May '14

08 May '14

International Chemical Discovery & Design Course, 16-27 June 2014, Nijmegen. We would like to draw your attention to the 10th annual International Chemical Discovery & Design Course (course website<http://www2.cmbi.ru.nl/groups/computational-discovery-and-design/icdd2014/>) which will be held from 16-27 June 2014 at the Radboud University Nijmegen. This course covers the recent advances in discovery informatics, with a focus on the application to real life problems. The course, combining practicals and lectures, will introduce and discuss different scientific concepts as well as providing an opportunity to gain practical experience using industry standard software. You can expect lectures and practicals on the following topics: * Introduction to Computational Discovery & Design * Comparative Protein Modelling * Sequence Retrieval, Analysis and Alignment Techniques * Computational Medicinal Chemistry; Molecular Descriptors & Library Design * The Application of Computational Drug Design to Real Life Problems * Molecular Docking and Virtual Screening * Advanced 3D Database Searches and Scaffold Hopping * QSAR and COMFA methods * Structure Based Drug Design Techniques Confirmed speakers: For the third time we were able to invite keynote speakers from the Netherlands and abroad. As experts in their field of research they will summarize the core message of the course in their presentations * Gerard JP van Westen, EBI, Hinxton, UK. ChEMBL: A large-scale open access bioactivity database for drug discovery and medicinal chemistry The course is targeted to MSc students, PhD students and post-docs. A basic background in bioinformatics or computational chemistry is a prerequisite for attendance. Registration via email to Barbara van Kampen<mailto:barbara.vankampen@radboudumc.nl>. Please, provide information about your background and your motivation to participate in the course. The course is free. You should however pay for travelling and lodging expenses yourself. Best regards Tina Ritschel (CDD/CMBI/UMC Nijmegen) Celia van Gelder (CMBI/RUN & Netherlands Bioinformatics Centre) You receive this email as participant in the NSBM mailing list ======================== --- Barbara van Kampen Operational manager [Radboudumckleine.png] CMBI 260 Radboud university medical center / RIMLS CMBI Office / Room 0.02 PO Box 9101 Geert-Grooteplein 26-28 6500 HB Nijmegen 6525 GA Nijmegen Phone: +31(0)24 36 19390 Fax: +31 (0)24 36 19395 www.cmbi.ru.nl<http://www.cmbi.ru.nl/> Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629. The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.

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Registration now open! - NBIC/BioSB Course Algorithms for Biological Networks (3th edition)
by Femke Francissen 08 May '14

08 May '14

NBIC/BioSB Course Algorithms for Biological Networks (3rd edition) - Registration open! Date: 30 June - 4 July, 2014 Course coordinators: Dick de Ridder (WUR), Jeroen de Ridder (TUD), Celia van Gelder (NBIC/BioSB) Location: Delft University of Technology (TUD), Delft, the Netherlands Website: http://biosb.nl/education/course-portfolio/bioinformatics-portfolio/course-… Registration: http://biosb.nl/education/enrollment-algorithms-for-biological-networks-cou… More information: education(a)biosb.nl<mailto:education@biosb.nl> Target audience PhD students with a background in bioinformatics, computer science or a related field; a working knowledge of basic statistics and linear algebra is assumed. Course Description In the third edition of this course, we will first give a brief overview of molecular biology, the advent of high-throughput measurement techniques and large databases containing biological knowledge, and the importance of networks to model all this. We will highlight a number of peculiar features of biological networks. Next, a number of basic network models (linear, Boolean, Bayesian) will be discussed, as well as methods of inferring networks from observed measurement data and of integrating various data sources and databases to refine networks. Once networks are derived they often serve as the cornerstone in the visualization, analysis and interpretation of high-throughput data; we will discuss a number of methods in this area. As an alternative to static networks, a number of alternative dynamic network models more suited for high-level simulation of cellular behaviour for will be introduced. Finally, we will give some examples of algorithms exploiting the networks found to learn about biology, specifically for inspecting protein interaction networks and for finding active sub networks. Course programme The course website, including full course programme, can be found at http://helix.ewi.tudelft.nl/nbic/abn/. BioSB Course Programme The course portfolios of NBIC (bioinformatics) and NCSB (systems biology) will be integrated and continued in the Netherlands Bioinformatics and Systems Biology Research School (BioSB). The Education Portfolio of BioSB can be found at http://biosb.nl/education/course-portfolio/. More information For more information about the course you can contact Celia van Gelder at education(a)biosb.nl<mailto:education@biosb.nl>. Dr. Celia W.G. van Gelder Coordinator Education CMBI Projectleader Education NBIC/BioSB tel. +31-(0)24-3666120 e-mail: Celia.vanGelder(a)radboudumc.nl<mailto:C.vanGelder@umcn.nl> websites: www.cmbi.ru.nl<http://www.cmbi.ru.nl/>, www.nbic.nl<http://www.nbic.nl/>, www.biosb.nl<http://www.biosb.nl> Postal address: CMBI 260 Radboud University Nijmegen-Medical Centre /NCMLS PO Box 9101, 6500 HB Nijmegen The Netherlands

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Registration now open! - NBIC/BioSB course Comparative Genomics, 2-6 June 2014
by Femke Francissen 08 May '14

08 May '14

NBIC/BioSB Course Comparative Genomics: from evolution to function (2nd edition) - Registration open! Date: June 2 - June 6, 2014 Location: VU University, Amsterdam, the Netherlands Course coordinators: Berend Snel (UU), Martijn Huynen (Radboudumc), Jaap Heringa (VU), Celia van Gelder (NBIC/BioSB, education(a)biosb.nl<mailto:education@biosb.nl>) Course website: http://biosb.nl/comparative-genomics-2014/ Registration: http://biosb.nl/education/enrollment-comparative-genomics/ More information: education(a)biosb.nl<mailto:education@biosb.nl> Course description Comparative genomics between species and between types of data facilitates the understanding of what these data really reflect about the underlying processes. Comparative genomics therewith relies on a solid understanding of basic elements of Bioinformatics like homology and orthology. Moreover it is important to know the assumptions and heuristics of bioinformatic methods for comparative genomics and hence we aim to let participants develop an understanding of why they fail (or misdetect) as a consequence of a variety of biological /evolutionary causes. The first two days of the course provide a basis for the course with the aim to move "beyond blast" in terms of more sensitive homology searches, domain level analysis of protein evolution as well as more fine grained definitions of relatedness as can be obtained from the proper interpretation of gene trees (i.e. various levels of orthology).This foundation is used to discuss in the three following days in more detail three topics: (1) the study of functional and evolutionary consequence of (genome) duplications, (2) the evolution of interactions and complexes and (3) the prediction and evolution of genomic regulatory elements. Target audience The course is intended for PhD students and master students in bioinformatics, especially those interested in evolution and/or those who want to compare various genomics data between species. Participants are expected to have some hands on experience with blast, constructing multiple sequence alignments and phylogenetic trees, and in addition to have some familiarity with concepts such as orthology, synteny and protein domains. Programme Monday June 2: Distant homology and protein domains (lecturer Jaap Heringa) Topics & Tools: Divergent and convergent evolution, (multiple) sequence alignment, psiblast, hhsearch, pfam, homology and function, undetected orthology from failure to detect homology, paralogs and function specificity prediction Tuesday June 3: Comparative Interactomics (lecturers Jaap Heringa, Martijn Huynen/John van Dam) Topics & Tools: network alignment, phylogenetic profiles, biogrid, cytoscape, Bayesian data integration, neofunctionalization vs subfunctionalization Wednesday June 4: Small scale orthology and large scale databases (lecturers Martijn Huynen, Berend Snel) Topics & Tools: tree reconciliation, relation between homology and orthology, ensembl compara, COGs, inparalogs vs outparalogs, fusion and fission Thursday June 5: Genome duplications (lecturer Berend Snel) Topics & Tools: yeast gene order browser, synteny, consequences of genome duplications, timing of duplications, ensembl biomart Friday June 6: Finding functional elements in DNA and RNA sequences, Biased gene conversion (lecturer Martijn Huynen) Topics & Tools: phylogenetic footprinting, (phylogeny aware) gibbs sampling, RNA secondary structure prediction based on sequences and on experimental data, biased gene conversion & positive selection. BioSB Course Programme The course portfolios of NBIC (bioinformatics) and NCSB (systems biology) will be integrated and continued in the Netherlands Bioinformatics and Systems Biology Research School (BioSB). The Education Portfolio of BioSB can be found at http://biosb.nl/education/course-portfolio/. More information For more information about the course you can contact Celia van Gelder at education(a)biosb.nl<mailto:education@biosb.nl>. Dr. Celia W.G. van Gelder Coordinator Education CMBI Projectleader Education NBIC tel. +31-(0)24-3666120 e-mail: Celia.vanGelder(a)radboudumc.nl<mailto:C.vanGelder@umcn.nl> websites: www.cmbi.ru.nl<http://www.cmbi.ru.nl/>, www.nbic.nl<http://www.nbic.nl/> Postal address: CMBI 260 Radboud University Nijmegen-Medical Centre /NCMLS PO Box 9101, 6500 HB Nijmegen The Netherlands Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629. The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.

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[Gtpb] REMINDER, new deadline. Structural Modeling for Large Macromolecular Complexes - SMLMC14 in Oeiras, Portugal
by Pedro Fernandes 07 May '14

07 May '14

GTPB Reminder Applications are open for another Bioinformatics Training course: SMLMC14 Structural Modeling for Large Macromolecular Complexes with Joanna Kasprzak and Grzegorz Chojnowski IMPORTANT DATES for this Course Deadline for applications: May 20th 2014 < New deadline Latest notification of acceptance: May 17th 2014 Course date: June 11th - June 13th 2014 For a reference about the use of the methodology: http://dx.doi.org/10.1016/j.ymeth.2013.09.014 *Computational modeling of proteinRNA complex structures* Irina Tuszynska, Dorota Matelska, Marcin Magnus, Grzegorz Chojnowski, Joanna M. Kasprzak, Lukasz P. Kozlowski, Stanislaw Dunin-Horkawicz, Janusz M. Bujnicki Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland Bioinformatics Laboratory, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, PL-61-614 Poznan, Poland *********************************************************************** Course description One of the major challenges in structural biology is to determine the structures of macromolecular complexes and to understand their function and mechanism of action. However, structural characterisation of macromolecular assemblies is very difficult. To begin addressing this problem, we have developed PyRy3D. In a nutshell, PyRy3D employs a hybrid computational approach that incorporates spatial information from a variety of experimental methods into the modelling procedure to build low-resolution models of large macromolecular complexes. The PyRy3D model building procedure uses a Monte Carlo approach to sample the solutions-space. It uses spatial restraints to define components interacting with each other, and a simple scoring function is applied to pack them tightly into contours of the entire complex (e.g. cryoEM density maps). More details at http://gtpb.igc.gulbenkian.pt/bicourses/SMLMC14/ Thank you for your interest! Pedro Fernandes GTPB Coordinator -- Pedro Fernandes Instituto Gulbenkian de Ciência Apartado 14 2781-901 OEIRAS PORTUGAL Tel +351 21 4407912 http://gtpb.igc.gulbenkian.pt _______________________________________________ Gtpb mailing list Gtpb(a)igc.gulbenkian.pt https://lists.igc.gulbenkian.pt/mailman/listinfo/gtpb

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3rd RSG Belgium seminar - reminder
by Jurgen CLAESEN 06 May '14

06 May '14

Dear all, We are very pleased to invite submissions for talks at the third RSG Belgium seminar. For more information about RSG Belgium, please have a look at the following link: http://www.iscbsc.org/rsg/rsg-belgium The goal of this seminar day is to allow PhD students from different research groups around Belgium to present their work and interact with each other. It will take place in *Antwerp* on Wednesday, the 28th of May 2014 from 14h to 17h. We will be accepting the first four submitted talks for this session. So don't wait too long to submit. The featured talks will have 20 minutes to present followed by about 10 minutes of questions. To submit a talk proposal, simply email rsg-belgium(a)iscbsc.org with the title of the talk and the name of the presenter. The submission deadline is Monday, the 19th of May. Please diffuse this call to anyone who might also be interested in joining. Hope to see you there! Best Regards, RSG Belgium committee

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REMINDER submit your abstract for ISCS2014!
by ISCBSC announcement 06 May '14

06 May '14

*ISCB Student Council Symposium 2014, Boston, USA.* Dear Colleagues, We are pleased to announce that the call is now open for the submission of abstracts to the 10th ISCB Student Council Symposium, to be held on the 11 of July 2014 in Boston, USA, as a satellite meeting of the International Conference on Intelligent Systems for Molecular Biology (ISMB). The Student Council Symposium is a forum for students, post docs, and young researchers in the fields of Computational Biology and Bioinformatics. Participants will have the opportunity to present their work to an international audience of young scientists, build a network within the computational biology community and develop important soft skills in an environment that fosters exchange of ideas and knowledge. We encourage you to submit an abstract to showcase your work at the Symposium’s poster session. As the central part of our symposium, 10 abstracts will be selected for an oral presentation. Awards will be given to outstanding posters and presentations. Travel fellowships will be available and candidates with accepted abstracts will be invited to apply. *Important Dates:* May 9, 2014: Abstract submission deadline May 16, 2014: Acceptance notifications May 23, 2014: Travel fellowship deadline June 4, 2014: Travel fellowship acceptance notification July 11, 2014: Student Council Symposium Submit your work at http://scs2014.iscbsc.org/scs14-call . For updates and news, keep an eye on symposium website http://scs2014.iscbsc.org/ . We look forward to receiving your abstract. On behalf of the SCS organizers, Farzana Rahman (Chair) Tomás Di Domenico (Co-Chair)

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[Gtpb] IBSTAT14 Introductory Biostatistics - Training course announcement
by Pedro Fernandes 01 May '14

01 May '14

GTPB Course Announcement IMPORTANT DATES for this Course Deadline for applications: May 15th 2014 Course date: June 2nd - June 6th 2014 This is one of our "Foundations" type courses, providing a systematic and detailed review of fundamental concepts and techniques in Biostatistics. Participants can expect to go through a set of exercises that are based on biomedical problems. These exercises are preceded by short lectures that are simple to follow. The lectures are designed to provide the conceptual framework that is needed to release the training power of the exercises, not to flood the participants with formality, which will be kept to a minimum. We will make use of a highly interactive methodology, taking advantage of our well equipped Bioinformatics training room. With this approach, we expect to bring the participants to a high degree of usage independence in using the methods that we cover. Main topics: Descriptive Statistics; Probability; Statistical Inference; Design of Experiments. More information, including instructions for applicants Thank you for your interest! Pedro Fernandes GTPB Coordinator -- Pedro Fernandes Instituto Gulbenkian de Ciência Apartado 14 2781-901 OEIRAS PORTUGAL Tel +351 21 4407912 http://gtpb.igc.gulbenkian.pt _______________________________________________ Gtpb mailing list Gtpb(a)igc.gulbenkian.pt https://lists.igc.gulbenkian.pt/mailman/listinfo/gtpb

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