Hi all, I've been thinking a bit about the problem of having multiple clustering solutions and combining these into 'consensus modules'. I don't know how much and along which lines you have been working on this problem, Tom ? My first thought was to somehow cluster the weighted summary graphs that Tom and Anagha produce with their software. Weighted bipartite graph clustering algorithms might be ideally suited for this, and there are apparently some algorithms and implementations available. I've attached a few relevant articles. We could think about: - clustering the weighted bipartite regulator-gene graph produced by the more recent Lemone 'S' versions - clustering similarly constructed bipartite regulator-condition graphs, as Eric suggested, to see which conditions matter for which regulators Let's discuss further after Tom gets back from holidays. S -- ================================================================== Steven Maere, PhD Dept. of Plant Systems Biology Bioinformatics & Evolutionary Genomics research group VIB / Ghent University Technologiepark 927 B-9052 Gent BELGIUM tel: +32 9 331 3810 fax: +32 9 331 3809 email: stmae@psb.UGent.be http://www.psb.UGent.be http://bioinformatics.psb.ugent.be/ ==================================================================