- Seminars - maillist.psb.ugent.be

Seminar Dr Pierre Rouzé 25/05
by Delphine Verspeel 14 May '12

14 May '12

You are receiving this e-mail because you subscribed to our seminars announcements and reminders service at <https://maillist.psb.ugent.be/mailman/listinfo/seminars> https://maillist.psb.ugent.be/mailman/listinfo/seminars. If you do not wish to receive this information anymore, please unsubscribe from future mailings at <https://maillist.psb.ugent.be/mailman/options/seminars> https://maillist.psb.ugent.be/mailman/options/seminars. cid:946540515@15122008-0D1C PSB cid:946540515@15122008-0D23 VIB - Department of Plant Systems Biology Technologiepark 927 B - 9052 Gent/Zwijnaarde Phone: +32 9 33 13 800 Fax: +32 9 33 13 809 Http://www.psb.vib-ugent.be

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PSB event reminder
by contact＠psb.vib-ugent.be 13 May '12

13 May '12

Calendar Name: seminars Scheduled for: Tuesday, May 15 2012, 13:00 - 14:30 Event text: Dr Mark Veugelers VIB Gent BELGIUM Details: �Technology Watch for access to breakthrough life science technologies� ABSTRACT VIB�s Technology Watch team continuously scans for novel technologies with disruptive potential in the life sciences and makes information on these technologies available throughout VIB. To reduce the risk of accessing high potential, but unproven technologies, the VIB Technology Watch team offers funding to VIB scientists for projects aimed at using these technologies. Limited Technology Watch funding is also available for access to recently commercialized technologies. Since 2009, more than 100 Technology Watch projects have been funded and in the meantime, several of these projects have led to high-impact publications. This presentation will present an overview of upcoming instrument-releases, services and commercial technologies with breakthrough potential in the life sciences and their applications in a wide range of fields: from DNA/RNA/Protein/Cellular analysis to imaging, synthetic biology, single-molecule analysis, high-throughput screening and beyond. Technology Watch funding for use of these high-potential technologies will be available to facilitate their adoption in VIB.

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PSB event reminder
by contact＠psb.vib-ugent.be 08 May '12

08 May '12

Calendar Name: seminars Scheduled for: Tuesday, May 8 2012, 14:00 - 15:30 Event text: Prof Salvador Moncada Wolfson Institute for Biomedical Research University College London London UNITED KINGDOM Details: �Connecting cell cycle progression to metabolic requirements� ABSTRACT Cell proliferation is accompanied by an increase in the utilization of glucose and glutamine. The proliferative response is dependent on a decrease in the activity of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdh1 which controls G1- to-S-phase transition by targeting degradation motifs, including the KEN box. This occurs not only in cell cycle proteins but also in the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), as we have demonstrated in cells in culture as well as in proliferating human T lymphocytes. Moreover, we have found that glutaminase 1 is a substrate for this ubiquitin ligase and appears at the same time as PFKFB3 in proliferating cells. Glutaminase 1 is the first enzyme in glutaminolysis and converts glutamine to glutamate, yielding intermediates for cell proliferation. Thus APC/C-Cdh1 is responsible for the increased utilization not only of glucose but also of glutamine and, as such, accounts for the critical step that links the cell cycle with the metabolic substrates essential for its progression. A further degree of control is provided by a second ubiquitin ligase � SCF (Skp1/CUL-1/F-box protein)--TrCP � which causes the disappearance of PFKFB3 during late G1/S. Thus the presence of PFKFB3 is tightly controlled to ensure the upregulation of glycolysis at a specific point in G1. The relevance of these observations to understanding of the proliferative and metabolic changes that occur in normal and in cancer cells will be discussed.

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Seminar Dr Mark Veugelers 15/05
by Delphine Verspeel 07 May '12

07 May '12

You are receiving this e-mail because you subscribed to our seminars announcements and reminders service at <https://maillist.psb.ugent.be/mailman/listinfo/seminars> https://maillist.psb.ugent.be/mailman/listinfo/seminars. If you do not wish to receive this information anymore, please unsubscribe from future mailings at <https://maillist.psb.ugent.be/mailman/options/seminars> https://maillist.psb.ugent.be/mailman/options/seminars. cid:946540515@15122008-0D1C PSB cid:946540515@15122008-0D23 VIB - Department of Plant Systems Biology Technologiepark 927 B - 9052 Gent/Zwijnaarde Phone: +32 9 33 13 800 Fax: +32 9 33 13 809 Http://www.psb.vib-ugent.be

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PSB event reminder
by contact＠psb.vib-ugent.be 06 May '12

06 May '12

Calendar Name: seminars Scheduled for: Tuesday, May 8 2012, 14:00 - 15:30 Event text: Prof Salvador Moncada Wolfson Institute for Biomedical Research University College London London UNITED KINGDOM Details: �Connecting cell cycle progression to metabolic requirements� ABSTRACT Cell proliferation is accompanied by an increase in the utilization of glucose and glutamine. The proliferative response is dependent on a decrease in the activity of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdh1 which controls G1- to-S-phase transition by targeting degradation motifs, including the KEN box. This occurs not only in cell cycle proteins but also in the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), as we have demonstrated in cells in culture as well as in proliferating human T lymphocytes. Moreover, we have found that glutaminase 1 is a substrate for this ubiquitin ligase and appears at the same time as PFKFB3 in proliferating cells. Glutaminase 1 is the first enzyme in glutaminolysis and converts glutamine to glutamate, yielding intermediates for cell proliferation. Thus APC/C-Cdh1 is responsible for the increased utilization not only of glucose but also of glutamine and, as such, accounts for the critical step that links the cell cycle with the metabolic substrates essential for its progression. A further degree of control is provided by a second ubiquitin ligase � SCF (Skp1/CUL-1/F-box protein)--TrCP � which causes the disappearance of PFKFB3 during late G1/S. Thus the presence of PFKFB3 is tightly controlled to ensure the upregulation of glycolysis at a specific point in G1. The relevance of these observations to understanding of the proliferative and metabolic changes that occur in normal and in cancer cells will be discussed.

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Seminar Prof Salvador Moncada 08/05
by Delphine Verspeel 27 Apr '12

27 Apr '12

You are receiving this e-mail because you subscribed to our seminars announcements and reminders service at <https://maillist.psb.ugent.be/mailman/listinfo/seminars> https://maillist.psb.ugent.be/mailman/listinfo/seminars. If you do not wish to receive this information anymore, please unsubscribe from future mailings at <https://maillist.psb.ugent.be/mailman/options/seminars> https://maillist.psb.ugent.be/mailman/options/seminars. cid:946540515@15122008-0D1C PSB cid:946540515@15122008-0D23 VIB - Department of Plant Systems Biology Technologiepark 927 B - 9052 Gent/Zwijnaarde Phone: +32 9 33 13 800 Fax: +32 9 33 13 809 Http://www.psb.vib-ugent.be

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Upcoming seminars May 2012
by Delphine Verspeel 27 Apr '12

27 Apr '12

Dear All, Enclosed you can find our upcoming seminars for May. Kind regards, Delphine ___________________________________________ Delphine Verspeel Administrative Assistant VIB, Department of Plant Systems Biology Ghent University Technologiepark 927 9052 Gent Belgium Phone: +32/9/33.13.800 Fax: +32/9/33.13.809 Http://www.psb.ugent.be despe(a)psb.vib-ugent.be

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PSB event reminder
by contact＠psb.vib-ugent.be 17 Apr '12

17 Apr '12

Calendar Name: seminars Scheduled for: Tuesday, April 17 2012, 14:00 - 15:30 Event text: Prof Jaideep Mathur Laboratory of Plant Development and Interactions Department of Molecular and Cellular Biology University of Guelph Guelph Ontario CANADA Details: �Organelle Extensions: Uncovering new facets of subcellular behaviour for maintaining homeostasis in plants� ABSTRACT Despite their inability to move away from stressful conditions, plants, in comparison to animals, have much longer life spans. How do plants manage stress while remaining 'rooted' to a spot? Perhaps, plant cells are able to respond to environmental stimuli rapidly and minimize subcellular stress levels before they become intolerable. Perhaps they do not need to move away! This fundamental thinking forms the basis for research in my lab. Using a judicious combination of molecular-genetic techniques including a wide range of targeted fluorescent protein probes, normal and mutant transgenic plants we have started uncovering the rapid sub-cellular response machinery in plants. We find that instead of dividing, many organelles extend their surfaces transiently by creating thin protrusions that can extend for considerable distances within the cell. This �primary� membrane-aided response prevents the build up of toxic by-products within the cell. Alternatively, organelle extensions are used for metabolite dispersal and exchange, as well as for �squeezing� past other organelles in narrow vacuole-dominated intracellular spaces. Notably, persistent stress acting on membranes does trigger molecular cascades that over a longer time scale result in division of organelles. Live-imaging of organelle extensions and their dynamic interactions challenges our view of the static plant cell built up using snapshots from fixed tissues and paves the way for a better understanding of plants and their rapid subcellular responses.

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PSB event reminder
by contact＠psb.vib-ugent.be 15 Apr '12

15 Apr '12

Calendar Name: seminars Scheduled for: Tuesday, April 17 2012, 14:00 - 15:30 Event text: Prof Jaideep Mathur Laboratory of Plant Development and Interactions Department of Molecular and Cellular Biology University of Guelph Guelph Ontario CANADA Details: �Organelle Extensions: Uncovering new facets of subcellular behaviour for maintaining homeostasis in plants� ABSTRACT Despite their inability to move away from stressful conditions, plants, in comparison to animals, have much longer life spans. How do plants manage stress while remaining 'rooted' to a spot? Perhaps, plant cells are able to respond to environmental stimuli rapidly and minimize subcellular stress levels before they become intolerable. Perhaps they do not need to move away! This fundamental thinking forms the basis for research in my lab. Using a judicious combination of molecular-genetic techniques including a wide range of targeted fluorescent protein probes, normal and mutant transgenic plants we have started uncovering the rapid sub-cellular response machinery in plants. We find that instead of dividing, many organelles extend their surfaces transiently by creating thin protrusions that can extend for considerable distances within the cell. This �primary� membrane-aided response prevents the build up of toxic by-products within the cell. Alternatively, organelle extensions are used for metabolite dispersal and exchange, as well as for �squeezing� past other organelles in narrow vacuole-dominated intracellular spaces. Notably, persistent stress acting on membranes does trigger molecular cascades that over a longer time scale result in division of organelles. Live-imaging of organelle extensions and their dynamic interactions challenges our view of the static plant cell built up using snapshots from fixed tissues and paves the way for a better understanding of plants and their rapid subcellular responses.

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PSB event reminder
by contact＠psb.vib-ugent.be 13 Apr '12

13 Apr '12

Calendar Name: seminars Scheduled for: Friday, April 13 2012, 14:00 - 15:30 Event text: Prof Enrico P� Institute of Life Sciences Scuola Superiore Sant'Anna di Pisa Pisa ITALY Details: �Quantitative Genomics: Exploring the genetic architecture of heterosis in maize� ABSTRACT The seminar will describe the approaches of quantitative genetics and genomics applied to identify heterotic QTL in maize and the difficult and somehow frustrating effort in trying to physically isolate the corresponding loci. In this seminar the development and fine genotypic characterization of near-isogenic lines for selected heterotic QTL will be described. Finally it will be presented a new large multi-parental population recently produced in maize and the challenge posed by its characterization.

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